Association of Lesion Location and Functional Parameters with Vision-Related Quality of Life in Geographic Atrophy Secondary to Age-related Macular Degeneration.

Autor:	Künzel SH; Department of Ophthalmology, University of Bonn, Bonn, Germany. Electronic address: sandrine.kuenzel@ukbonn.de., Broadbent E; Department of Ophthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah., Möller PT; Department of Ophthalmology, University of Bonn, Bonn, Germany., Lindner M; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University, Marburg, Germany; Nuffield Laboratory of Ophthalmology, Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Goerdt L; Department of Ophthalmology, University of Bonn, Bonn, Germany., Czauderna J; Department of Ophthalmology, University of Bonn, Bonn, Germany., Schmitz-Valckenberg S; Department of Ophthalmology, University of Bonn, Bonn, Germany; Department of Ophthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah., Holz FG; Department of Ophthalmology, University of Bonn, Bonn, Germany., Pfau M; Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland., Fleckenstein M; Department of Ophthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
Jazyk:	angličtina
Zdroj:	Ophthalmology. Retina [Ophthalmol Retina] 2024 Aug; Vol. 8 (8), pp. 794-803. Date of Electronic Publication: 2024 Feb 03.
DOI:	10.1016/j.oret.2024.01.025
Abstrakt:	Objective: The primary goal of this study was to determine how structural and functional parameters influence the vision-related quality of life (VRQoL) in patients suffering from geographic atrophy (GA) secondary to age-related macular degeneration. Design: This study was designed as a prospective, noninterventional, natural-history study (Directional Spread in Geographic-Atrophy study, NCT02051998). Subjects: The research involved 82 patients with bilateral GA. Methods: The study examined parameters including GA location as assessed by the ETDRS grid, best-corrected visual acuity, low-luminance visual acuity (LLVA), reading acuity, and speed. These parameters were then correlated with VRQoL, which was gauged using the National Eye Institute Visual Function Questionnaire 25. The analysis method employed was the least absolute shrinkage and selection operator with linear mixed-effects models. Main Outcome Measures: The central parameters measured in this study encompassed GA area, VRQoL scores associated with different GA subfields, and the significance of LLVA for foveal-sparing patients. Results: On average, patients showed a total GA area of 2.9 ± 1.2 mm 2 in the better eye (BE) and 3.1 ± 1.3 mm 2 in the worse eye. The most significant associations with VRQoL scores for distance and near activities were observed in the inner lower and inner left subfields of the BE, respectively. For patients with foveal-sparing GA, the LLVA of the BE stood out as the most influential variable across all VRQoL scales. Conclusions: The study's findings point toward the pivotal role of GA location, especially the inner lower and inner left subfields of the BE, in relation to VRQoL in GA patients. The LLVA's importance becomes even more pronounced for foveal-sparing patients. These observations highlight the need for health care professionals to better understand the association between lesion location and patient-reported outcomes. This is critical for informing treatment decisions and refining the planning of interventional trials. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. (Copyright © 2024 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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