Acute Kidney Injury Resulting From Hemoglobinuria After Pulsed-Field Ablation in Atrial Fibrillation: Is it Preventable?

Autor:	Mohanty S; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Casella M; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Compagnucci P; Department of Electrophysiology, Ospedali Riuniti Hospital, Ancona, Italy., Torlapati PG; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Della Rocca DG; Department of Cardiology, University Hospital, Brussels, Belgium., La Fazia VM; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Gianni C; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Chierchia GB; Department of Cardiology, University Hospital, Brussels, Belgium., MacDonald B; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Mayedo A; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Khan UN; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Allison J; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Bassiouny M; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Gallinghouse GJ; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Burkhardt JD; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Horton R; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Al-Ahmad A; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA., Di Biase L; Department of Electrophysiology, Albert Einstein College of Medicine at Montefiore Hospital, New York, New York, USA., de Asmundis C; Department of Cardiology, University Hospital, Brussels, Belgium., Russo AD; Department of Electrophysiology, Ospedali Riuniti Hospital, Ancona, Italy., Natale A; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA; Department of Electrophysiology, Albert Einstein College of Medicine at Montefiore Hospital, New York, New York, USA; Interventional Electrophysiology, Scripps Clinic, San Diego, California, USA; Department of Internal Medicine, Metro Health Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Electronic address: dr.natale@gmail.com.
Jazyk:	angličtina
Zdroj:	JACC. Clinical electrophysiology [JACC Clin Electrophysiol] 2024 Apr; Vol. 10 (4), pp. 709-715. Date of Electronic Publication: 2024 Feb 01.
DOI:	10.1016/j.jacep.2023.12.008
Abstrakt:	Background: High-voltage pulses can cause hemolysis. Objectives: The authors evaluated the occurrence of hemoglobinuria after pulsed-field ablation (PFA) and its impact on renal function in patients with atrial fibrillation (AF). Methods: A consecutive series of patients with AF undergoing PFA were included in this analysis. The initial patients who did not receive postablation hydration immediately after the procedure were classified as group 1 (n = 28), and the rest of the study patients who received planned fluid infusion (0.9% sodium chloride ≥2 L) after the procedure were categorized as group 2 (n = 75). Results: Of the 28 patients in group 1, 21 (75%) experienced hemoglobinuria during the 24 hours after catheter ablation. The mean postablation serum creatinine (S-Cr) was significantly higher than the baseline value in those 21 patients (1.46 ± 0.28 mg/dL vs 0.86 ± 0.24 mg/dL, P < 0.001). Of those 21 patients, 4 (19%) had S-Cr. >2.5 mg/dL (mean: 2.95 ± 0.21 mg/dL). The mean number of PF applications was significantly higher in those 4 patients than in the other 17 patients experiencing hemoglobinuria (94.63 ± 3.20 vs 46.75 ± 9.10, P < 0.001). In group 2 patients, no significant changes in S-Cr were noted. The group 2 patients received significantly higher amounts of fluid infusion after catheter ablation than did those in group 1 (2,082.50 ± 258.08 mL vs 494.01 ± 71.65 mL, P < 0.001). In multivariable analysis, both hydration (R 2  = 0.63, P < 0.01) and number of PFA applications (R 2  = 0.33, P < 0.01) were independent predictors of postprocedure acute kidney injury. Conclusions: On the basis of our findings, both the number of PFA applications and postablation hydration were independent predictors of renal insult that could be prevented using planned fluid infusion immediately after the procedure. Competing Interests: Funding Support and Author Disclosures Dr. Chierchia has received compensation for teaching purposes and proctoring from Medtronic, Abbott, Biotronik, Boston Scientific, and Acutus Medical. Dr. Burkhardt is a consultant for Biosense Webster and Stereotaxis. Dr. Di Biase is a consultant for Biosense Webster, Boston Scientific, Stereotaxis, and St. Jude Medical and has received speaker honoraria from Medtronic, Atricure, EPiEP, and Biotronik. Dr. de Asmundis has received research grants on behalf of the center from Biotronik, Medtronic, Abbott, LivaNova, Boston Scientific, AtriCure, Philips, and Acutus and compensation for teaching purposes and proctoring from Medtronic, Abbott, Biotronik, Livanova, Boston Scientific, Atricure, Acutus Medical, and Daiichi Sankyo. Dr. Dello Russo is a consultant for Abbott Medical. Dr, Natale is a consultant for Abbott, Biosense Webster, Biotronik, Boston Scientific, and iRhythm. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (Copyright © 2024 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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