Skin care by washing with water is not inferior to washing with a cleanser in children with atopic dermatitis in remission in summer: WASH study.

Autor:	Katoh Y; Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan., Natsume O; Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan. Electronic address: natsumeo@hama-med.ac.jp., Yasuoka R; Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan., Hayano S; The Allergic Disease Research Center and the Department of Pediatrics, Chutoen General Medical Center, Shizuoka, Japan., Okada E; Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan; Faculty of Social Policy and Administration, Hosei University, Tokyo, Japan., Ito Y; Department of Pediatrics, Iwata City Hospital, Shizuoka, Japan., Sakai A; Department of Pediatrics, Hamamatsu Medical Center, Shizuoka, Japan., Monna Y; Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan., Takayanagi F; Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan., Inuzuka Y; Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan., Sakakura Y; Department of Pediatrics, JA Shizuoka Kohseiren Enshu Hospital, Shizuoka, Japan.
Jazyk:	angličtina
Zdroj:	Allergology international : official journal of the Japanese Society of Allergology [Allergol Int] 2024 Jul; Vol. 73 (3), pp. 428-435. Date of Electronic Publication: 2024 Feb 02.
DOI:	10.1016/j.alit.2024.01.007
Abstrakt:	Background: Washing with water is not inferior to washing with soaps and detergents in children with atopic dermatitis (AD) in remission during the fall-winter seasons. We investigated whether this finding varies during summer based on the type of cleanser (soaps and detergents). Methods: This evaluator-blinded, pragmatic, randomized, and non-inferiority study enrolled patients with AD whose eczema was controlled following regular steroid ointment application 2 days/week. For 8 ± 4 weeks, participants washed their upper and lower limbs with a cleanser on one side and with water alone on the other. Each participant chose either a weakly alkaline soap or an acidic detergent. The primary outcome was the Eczema Area and Severity Index (EASI) score at week 8 ± 4. Results: The data of 43 of the 47 registered participants were analyzed. The median patient age was 44 (23-99) months; 28 and 15 participants chose weakly alkaline and acidic cleansers, respectively. At week 8 ± 4, EASI scores of the water and cleanser sides were 0.00 (0.00-0.40) and 0.15 (0.00-0.40), respectively (p = 0.74). The difference between both sides was 0.00 (-0.07 to 0.14); the limits of the 95 % confidence interval did not reach the pre-specified non-inferiority margin. No difference was observed in the median Patient-Oriented Eczema Measure score, number of additional steroid ointment applications, and occurrences of skin infections. There were no differences between the cleanser types in any of the results. Conclusions: We demonstrated that washing with water was not inferior to that with a cleanser in patients with AD in the maintenance phase during summer, regardless of the type of cleanser. (Copyright © 2024 Japanese Society of Allergology. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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