Patient-reported outcomes at three months after pancreatic surgery for benign and malignant diseases - A prospective observational study.
Autor: | Ten Winkel M; Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany., Salama H; Department of Surgery, St. Joseph-Hospital, Ruhr University Bochum, Germany., Timrott K; Department of Surgery, University Hospital, Medical School Hannover, Germany., Kleine M; Department of Surgery, University Hospital, Medical School Hannover, Germany; Department of Surgery, Vinzenz Hospital Hannover, Germany., Kleine-Doepke D; Department of Surgery, University Hospital, Medical School Hannover, Germany., Raehder-Johnson S; Department of Surgery, Hospital Winsen, Germany., Meisel H; Department of Surgery, Hospital Winsen, Germany., Rahberi NN; Department of Surgery, University Medical Center Mannheim, Germany., Abdelhadi S; Department of Surgery, University Medical Center Mannheim, Germany., Rückert F; Department of Surgery, University Medical Center Mannheim, Germany; Department of Surgery, Diakonissen Hospital Speyer, Germany., Reissfelder C; Department of Surgery, University Medical Center Mannheim, Germany., Honselmann KC; Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany., Braun R; Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany., Faerber B; Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany., Lapshyn H; Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany., Keck T; Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany. Electronic address: Tobias.Keck@uksh.de., Uhl W; Department of Surgery, St. Joseph-Hospital, Ruhr University Bochum, Germany., Belyaev O; Department of Surgery, St. Joseph-Hospital, Ruhr University Bochum, Germany., Wellner UF; Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany., Bolm L; Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany. |
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Jazyk: | angličtina |
Zdroj: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2024 Mar; Vol. 24 (2), pp. 314-322. Date of Electronic Publication: 2024 Jan 18. |
DOI: | 10.1016/j.pan.2024.01.007 |
Abstrakt: | Background/objectives: Pancreatic surgery may have a long-lasting effect on patients' health status and quality of life (QoL). We aim to evaluate patient-reported outcomes (PRO) 3 months after pancreatic surgery. Methods: Patients scheduled for pancreatic surgery were enrolled in a prospective trial at five German centers. Patients completed PRO questionnaires (EQ-5D-5L, EORTC QLQ-PAN26, patient-reported happiness, and HADS-D), we report the first follow-up 3 months after surgery as an interim analysis. Statistical testing was performed using R software. Results: From 2019 to 2022 203 patients were enrolled, a three-month follow-up questionnaire was available in 135 (65.5 %). 77 (57.9 %) underwent surgery for malignant disease. Patient-reported health status (EQ-5D-5L) was impaired in 4/5 dimensions (mobility, self-care, usual activities, pain, discomfort) for patients with malignant and 3/5 dimensions (mobility, self-care, usual activities) for patients with benign disease 3 months after surgery (p < 0.05). Patients with malignant disease reported an increase in depressive symptoms, patients with benign disease had a decrease in anxiety symptoms (HADS-D; depression: 5.00 vs 6.51, p = 0.002; anxiety: 8.04 vs. 6.34, p = 0.030). Regarding pancreatic-disease-specific symptoms (EORTC-QLQ-PAN26), patients with malignant disease reported increased problems with taste, weight loss, weakness in arms and legs, dry mouth, body image and troubling side effects at three months. Patients with benign disease indicated more weakness in arms and legs, troubling side effects but less future worries at three months. Conclusion: Patient-reported outcomes of patients undergoing pancreatic surgery for benign vs. malignant disease show important differences. Patients with malignant tumors report more severely decreased quality of life 3 months postoperatively than patients with benign tumors. Competing Interests: Declaration of competing interest None of the authors has a conflict of interest. (Copyright © 2024. Published by Elsevier B.V.) |
Databáze: | MEDLINE |
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