Pharmacological interventions in human aging.

Autor: Petr MA; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Matiyevskaya F; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Osborne B; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Berglind M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Reves S; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Zhang B; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Ezra MB; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Carmona-Marin LM; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Syadzha MF; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Mediavilla MC; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Keijzers G; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Bakula D; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Mkrtchyan GV; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark., Scheibye-Knudsen M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address: mscheibye@sund.ku.dk.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2024 Mar; Vol. 95, pp. 102213. Date of Electronic Publication: 2024 Feb 02.
DOI: 10.1016/j.arr.2024.102213
Abstrakt: Pharmacological interventions are emerging as potential avenues of alleviating age-related disease. However, the knowledge of ongoing clinical trials as they relate to aging and pharmacological interventions is dispersed across a variety of mediums. In this review we summarize 136 age-related clinical trials that have been completed or are ongoing. Furthermore, we establish a database that describe the trials (AgingDB, www.agingdb.com) keeping track of the previous and ongoing clinical trials, alongside their outcomes. The aim of this review and database is to give people the ability to easily query for their trial of interest and stay up to date on the latest results. In sum, herein we give an overview of the current pharmacological strategies that have been applied to target human aging.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Morten Scheibye-Knudsen reports financial support was provided by Novo Nordisk Foundation. Morten Scheibye-Knudsen reports financial support was provided by Nordea Foundation. Morten Scheibye-Knudsen reports financial support was provided by Neye Foundation. Morten Scheibye-Knudsen reports financial support was provided by Lundbeck Foundation. Morten Scheibye-Knudsen reports financial support was provided by Danish Ministry of Higher Education and Science. Morten Scheibye-Knudsen reports financial support was provided by VitaDAO. Morten Scheibye-Knudsen reports financial support was provided by Insilico Medicine.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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