Are telocytes related to maintenance of vascular homeostasis in normal and pathological aorta?

Autor: Borges LF; Morphophysiology & Pathology Sector, Biological Sciences Department, Federal University of São Paulo, Diadema, SP, Brazil. Electronic address: lucianoborgesunifesp@gmail.com., Falcão RSP; School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Taboga SR; Department of Biology, State University of São Paulo, São José do Rio Preto, SP, Brazil., Gutierrez PS; Heart Institute (InCor), School of Medicine, University of São Paulo, SP, Brazil., Michel JB; LVTS, University of Paris, Paris, France.
Jazyk: angličtina
Zdroj: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology [Cardiovasc Pathol] 2024 May-Jun; Vol. 70, pp. 107617. Date of Electronic Publication: 2024 Feb 01.
DOI: 10.1016/j.carpath.2024.107617
Abstrakt: The telocyte (TC) is a new interstitial cell type described in a wide variety of organs and loose connective tissues around small vessels, but its presence in large arteries remains unexplored. TCs have small cell bodies and remarkably thin, long, moniliform processes called telopods (Tps). Using transmission electron microscopy and immunofluorescence, we identified TCs in normal human thoracic aortas and in those with aneurysm or acute dissection (TAAD). In normal aortas the TCs were distributed throughout the connective tissue of the adventitial layer, in its innermost portion and at the zone of transition with the medial layer, with their long axes oriented parallel to the external elastic lamellae, forming a three-dimensional network, without prevalence in the media layer. In contrast, TAAD TCs were present in the medial layer and in regions of neovascularization. The most important feature of the adventitia of diseased aortas was the presence of numerous contacts between TCs and stem cells, including vascular progenitor cells. Although the biologically functional correlations need to be elucidated, the morphological observations presented here provide strong evidence of the involvement of TCs in maintaining vascular homeostasis in pathological situations of tissue injury.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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