New peperomin and polyketides from dichloromethane extract of Peperomia blanda Jack. (Kunth).

Autor:	Al-Madhagi WM; Pharmaceutical Medicinal and Organic Chemistry, Faculty of Pharmacy, Sana'a University, 31220 Sana'a, Yemen.; Faculty of Pharmacy, University of Malaya, 50603 Kuala Lumpur, Malaysia.; Faculty of Medicine, Al Naser University, 31220 Sana'a, Yemen., Sharhan O; Chemistry Department, Faculty of Science, University of Malaya (UM), 50603 Kuala Lumpur, Malaysia.; Chemistry Department, Faculty of Education, Thamar University, Yemen., Jadan B; Pharmaceutical Medicinal and Organic Chemistry, Faculty of Pharmacy, Sana'a University, 31220 Sana'a, Yemen., Hashim NM; Faculty of Medicine, Al Naser University, 31220 Sana'a, Yemen.; Center for Natural Products Research and Drug Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia., Awadh N; Department of Pharmacognosy, Faculty of Pharmacy, Sana'a University, 31220 Sana'a, Yemen.; Department of Pharmacognosy, Faculty of Clinical Pharmacy, Albaha University,65431 Albaha, Kingdom of Saudi Arabia., Othman R; Faculty of Medicine, Al Naser University, 31220 Sana'a, Yemen.; Center for Natural Products Research and Drug Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia.; Drug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, Malaysia.
Jazyk:	angličtina
Zdroj:	Tropical biomedicine [Trop Biomed] 2023 Dec 01; Vol. 40 (4), pp. 486-496.
DOI:	10.47665/tb.40.4.015
Abstrakt:	Much of the new research and investigation in pharmacy sciences are concerned with developing therapeutic agents, and identifying and finding new drugs with their chemical structure to treat different human diseases such as infectious diseases from natural products. Therefore, the present findings relate to isolating five new compounds the dichloromethane extract of Peperomia blanda (Jacq.) Kunth grown on Socotra Island, Yemen. two new secolignans; which have been proposed as peperomin I & J. These compounds were isolated together with the other two polyketides presented as surinone D and dindygulerione F. The chemical structures were elucidated and confirmed with nuclear magnetic resonance (NMR) and liquid chromatography-mass spectroscopy (LCMS) analysis. These compounds were first isolated and reported from this plant. These new compounds' antimicrobial activity has been evaluated, and minimum inhibitory concentration has been recorded in the range of 125-250 µg/mL. The pharmacotherapeutic spectrum of compounds was predicated using PASS software which showed potential activity.
Databáze:	MEDLINE
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