Movement efficiency in survivors of childhood acute lymphoblastic leukemia: a report from the St. Jude lifetime cohort study.

Autor: Onerup A; Department of Epidemiology and Cancer Control, St. Jude Children´s Research Hospital, Memphis, TN, USA. aron.onerup@gu.se.; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. aron.onerup@gu.se., Mirzaei S S; Department of Biostatistics, St Jude Children´s Research Hospital, Memphis, TN, USA., Wogksch MD; Department of Epidemiology and Cancer Control, St. Jude Children´s Research Hospital, Memphis, TN, USA., Goodenough CG; Department of Epidemiology and Cancer Control, St. Jude Children´s Research Hospital, Memphis, TN, USA., Lambert G; Department of Epidemiology and Cancer Control, St. Jude Children´s Research Hospital, Memphis, TN, USA., Sapkota Y; Department of Epidemiology and Cancer Control, St. Jude Children´s Research Hospital, Memphis, TN, USA., Mulrooney DA; Department of Epidemiology and Cancer Control, St. Jude Children´s Research Hospital, Memphis, TN, USA.; Department of Oncology, St Jude Children´s Research Hospital, Memphis, TN, USA., Hudson MM; Department of Epidemiology and Cancer Control, St. Jude Children´s Research Hospital, Memphis, TN, USA.; Department of Oncology, St Jude Children´s Research Hospital, Memphis, TN, USA., Jacola LM; Department of Psychology, St Jude Children´s Research Hospital, Memphis, TN, USA., Ness KK; Department of Epidemiology and Cancer Control, St. Jude Children´s Research Hospital, Memphis, TN, USA.
Jazyk: angličtina
Zdroj: Journal of cancer survivorship : research and practice [J Cancer Surviv] 2024 Feb 03. Date of Electronic Publication: 2024 Feb 03.
DOI: 10.1007/s11764-024-01550-1
Abstrakt: Purpose: Movement efficiency, a measure of neuromuscular biomechanics, may be modified by physical activity. We aimed to assess the risk of and risk factors for low movement efficiency in survivors of childhood acute lymphoblastic leukemia (ALL).
Methods: Participants underwent an assessment of activity energy expenditure (AEE) with actigraphy, and the gold standard doubly labeled water, where the differences between elimination rates of oxygen and hydrogen from body water are evaluated over a week. Movement efficiency was assessed using the raw residuals of a linear regression between AEEs from accelerometers and doubly labeled water. Elastic-net logistic regressions were used to identify demographic, treatment, and functional variables associated with movement efficiency.
Results: The study cohort included 256 non-cancer controls and 302 ALL survivors (48% female), categorized as efficient (N = 24), normal (N = 245), or inefficient (N = 33) based on their movement efficiency. There was no difference in the odds for poor movement efficiency between survivors (n = 33, 10.9%) compared to controls (n = 23, 9.0%, odds ratio [OR]: 1.19, 95% confidence interval [CI]: 0.67, 2.10; p = 0.55). In survivors, neuropathy was associated with a higher risk of being inefficient compared to efficient (OR 4.30, 95% CI 1.03-17.96), while obesity (≥ 30 kg/m 2 ) had a protective association (OR 0.18, 95% CI 0.04-0.87).
Conclusions: Neuropathy was associated with a higher risk of poor movement efficiency in survivors of childhood ALL.
Implications for Cancer Survivors: These results further highlight impairments associated with treatment-induced neuropathy in survivors of childhood ALL.
(© 2024. The Author(s).)
Databáze: MEDLINE
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