Licochalcone A induces endoplasmic reticulum stress-mediated apoptosis of endometrial cancer cells via upregulation of GRP78 expression.

Autor: Wu MH; Laboratory Department, Chung-Kang Branch, Cheng-Ching General Hospital, Taichung, Taiwan., Hsieh YH; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan., Lin CL; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Ying TH; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan., Hsia SM; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan., Hsieh SC; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan., Lee CH; Division of Pediatric Surgery, Department of Surgery, Children's Hospital of China Medical University, Taichung, Taiwan.; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan., Lin CL; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Jazyk: angličtina
Zdroj: Environmental toxicology [Environ Toxicol] 2024 May; Vol. 39 (5), pp. 2961-2969. Date of Electronic Publication: 2024 Feb 02.
DOI: 10.1002/tox.24156
Abstrakt: Licochalcone A (LicA), a natural compound extracted from licorice root, has been shown to exert a variety of anticancer activities. Whether LicA has such effects on endometrial cancer (EMC) is unclear. This study aims to investigate the antitumor effects of LicA on EMC. Our results show that LicA significantly reduced the viability and induced apoptosis of EMC cells and EMC-7 cells from EMC patients. LicA was also found to induce endoplasmic reticulum (ER) stress, leading to increased expression of ER-related proteins (GRP78/PERK/IRE1α/CHOP) in EMC cell lines. Suppression of GRP78 expression in human EMC cells treated with LicA significantly attenuated the effects of LicA, resulting in reduced ER-stress mediated cell apoptosis and decreased expression of ER- and apoptosis-related proteins. Our findings demonstrate that LicA induces apoptosis in EMC cells through the GRP78-mediated ER-stress pathway, emphasizing the potential of LicA as an anticancer therapy for EMC.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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