Anodal transcranial direct-current stimulation and non-verbal intelligence in autism spectrum disorder: A randomized controlled trial.

Autor: Ratsapbhayakul T; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Keeratitanont K; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Radiology and Nuclear Medicine, Faculty of Medicine Burapha University, Chonburi, Thailand., Chonprai C; Division of Child Psychiatry, Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Auvichayapat N; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Suphakunpinyo C; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Patjanasoontorn N; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Division of Child Psychiatry, Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Tiamkao S; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Division of Neurology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Tunkamnerdthai O; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Punjaruk W; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Auvichayapat P; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Jazyk: angličtina
Zdroj: Developmental medicine and child neurology [Dev Med Child Neurol] 2024 Sep; Vol. 66 (9), pp. 1244-1254. Date of Electronic Publication: 2024 Feb 02.
DOI: 10.1111/dmcn.15874
Abstrakt: Aim: To understand the impact of anodal transcranial direct-current stimulation (tDCS) on non-verbal intelligence in high-functioning young adults with autism spectrum disorder (ASD).
Method: Thirty individuals with ASD were randomly divided into three groups receiving 2 mA, 20 minutes daily anodal tDCS for 10 sessions. Group A received 10 sham tDCS sessions, group B five real followed by five sham sessions, and group C received 10 real tDCS sessions. The total score of non-verbal intelligence was measured using the Test of Nonverbal Intelligence, Fourth Edition. The left dorsolateral prefrontal cortex (LDLPFC) was targeted using the International 10-20 electroencephalography system, and concurrent cognitive training was avoided.
Results: Group C demonstrated a mean difference of 4.10 (95% confidence interval 1.41-6.79; p = 0.005) in Test of Nonverbal Intelligence scores compared with group A, with an effect size of 0.47. No significant differences were observed between groups A and B (p = 0.296), or between groups B and C (p = 0.140).
Interpretation: Ten sessions of anodal tDCS to the LDLPFC led to improved non-verbal intelligence among individuals with ASD. These results emphasize the potential of tDCS as a discrete method for boosting cognitive abilities in the high-functioning population with ASD. Future studies with larger groups of participants and extended observation periods are necessary to validate these findings.
(© 2024 Mac Keith Press.)
Databáze: MEDLINE
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