Effect of inhaled oxygen level on dynamic glucose-enhanced MRI in mouse brain.

Autor: Huang J; Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China., Chen Z; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China., van Zijl PCM; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.; Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Hin Law L; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China., Pemmasani Prabakaran RS; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China., Park SW; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China., Xu J; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.; Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Chan KWY; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.; Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China.; City University of Hong Kong Shenzhen Research Institute, Shenzhen, China.; Tung Biomedical Science Centre, City University of Hong Kong, Hong Kong, China.
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2024 Jul; Vol. 92 (1), pp. 57-68. Date of Electronic Publication: 2024 Feb 02.
DOI: 10.1002/mrm.30035
Abstrakt: Purpose: To investigate the effect of inhaled oxygen level on dynamic glucose enhanced (DGE) MRI in mouse brain tissue and CSF at 3 T.
Methods: DGE data of brain tissue and CSF from mice under normoxia or hyperoxia were acquired in independent and interleaved experiments using on-resonance variable delay multi-pulse (onVDMP) MRI. A bolus of 0.15 mL filtered 50% D-glucose was injected through the tail vein over 1 min during DGE acquisition. MRS was acquired before and after DGE experiments to confirm the presence of D-glucose.
Results: A significantly higher DGE effect under normoxia than under hyperoxia was observed in brain tissue (p = 0.0001 and p = 0.0002 for independent and interleaved experiments, respectively), but not in CSF (p > 0.3). This difference is attributed to the increased baseline MR tissue signal under hyperoxia induced by a shortened T 1 and an increased BOLD effect. When switching from hyperoxia to normoxia without glucose injection, a signal change of ˜3.0% was found in brain tissue and a signal change of ˜1.5% was found in CSF.
Conclusions: DGE signal was significantly lower under hyperoxia than that under normoxia in brain tissue, but not in CSF. The reason is that DGE effect size of brain tissue is affected by the baseline signal, which could be influenced by T 1 change and BOLD effect. Therefore, DGE experiments in which the oxygenation level is changed from baseline need to be interpreted carefully.
(© 2024 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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