Associations of Lifestyle Patterns with Glucose and Lipid Metabolism in Finnish Adults at Increased Risk of Type 2 Diabetes.

Autor: Manninen S; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70211, Finland., Tilles-Tirkkonen T; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70211, Finland., Aittola K; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70211, Finland., Männikkö R; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70211, Finland., Karhunen L; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70211, Finland., Kolehmainen M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70211, Finland., Schwab U; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70211, Finland.; Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, KYS, 70029, Finland., Lindström J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, 00271, Finland., Lakka T; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, 70211, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, KYS, 70029, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Pihlajamäki J; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70211, Finland.; Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, KYS, 70029, Finland.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2024 Mar; Vol. 68 (5), pp. e2300338. Date of Electronic Publication: 2024 Feb 02.
DOI: 10.1002/mnfr.202300338
Abstrakt: Scope: Various lifestyle and sociodemographic factors have been associated with risk factors for type 2 diabetes (T2D). However, their combined associations with T2D risk factors have been studied much less.
Materials and Results: This study investigates cross-sectional associations of lifestyle patterns with T2D risk factors among 2925 adults at increased risk participating in the Stop Diabetes study. Lifestyle patterns are determined using principal component analysis (PCA) with several lifestyle and sociodemographic factors. The associations of lifestyle patterns with measures of glucose and lipid metabolism and serum metabolites analyzed by nuclear magnetic resonance (NMR) spectroscopy are studied using linear regression analysis. "Healthy eating" pattern is associated with better glucose and insulin metabolism, more favorable lipoprotein and fatty acid profiles and lower serum concentrations of metabolites related to inflammation, insulin resistance, and T2D. "High socioeconomic status and low physical activity" pattern is associated with increased serum concentrations of branched-chain amino acids, as are "Meat and poultry" and "Sleeping hours" patterns. "Snacks" pattern is associated with lower serum concentrations of ketone bodies.
Conclusions: Our results show, in large scale primary care setting, that healthy eating is associated with better glucose and lipid metabolism and reveal novel associations of lifestyle patterns with metabolites related to glucose metabolism.
(© 2024 The Authors. Molecular Nutrition & Food Research published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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