Triple dissociation of visual, auditory and motor processing in mouse primary visual cortex.

Autor: Oude Lohuis MN; Cognitive and Systems Neuroscience Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands.; Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands.; Champalimaud Neuroscience Programme, Champalimaud Foundation, Lisbon, Portugal., Marchesi P; Cognitive and Systems Neuroscience Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands.; Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands., Olcese U; Cognitive and Systems Neuroscience Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands.; Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands., Pennartz CMA; Cognitive and Systems Neuroscience Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands. c.m.a.pennartz@uva.nl.; Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands. c.m.a.pennartz@uva.nl.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2024 Apr; Vol. 27 (4), pp. 758-771. Date of Electronic Publication: 2024 Feb 02.
DOI: 10.1038/s41593-023-01564-5
Abstrakt: Primary sensory cortices respond to crossmodal stimuli-for example, auditory responses are found in primary visual cortex (V1). However, it remains unclear whether these responses reflect sensory inputs or behavioral modulation through sound-evoked body movement. We address this controversy by showing that sound-evoked activity in V1 of awake mice can be dissociated into auditory and behavioral components with distinct spatiotemporal profiles. The auditory component began at approximately 27 ms, was found in superficial and deep layers and originated from auditory cortex. Sound-evoked orofacial movements correlated with V1 neural activity starting at approximately 80-100 ms and explained auditory frequency tuning. Visual, auditory and motor activity were expressed by different laminar profiles and largely segregated subsets of neuronal populations. During simultaneous audiovisual stimulation, visual representations remained dissociable from auditory-related and motor-related activity. This three-fold dissociability of auditory, motor and visual processing is central to understanding how distinct inputs to visual cortex interact to support vision.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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