Malaria seroepidemiology in very low transmission settings in the Peruvian Amazon.

Autor: Fernandez-Camacho B; Health Innovation Laboratory, Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru. bryan.fernandez.c@upch.pe., Peña-Calero B; Health Innovation Laboratory, Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru., Guillermo-Roman M; Health Innovation Laboratory, Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru., Ruiz-Cabrejos J; Health Innovation Laboratory, Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru., Barboza JL; Health Innovation Laboratory, Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru., Bartolini-Arana L; Health Innovation Laboratory, Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru., Barja-Ingaruca A; Health Innovation Laboratory, Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru., Rodriguez-Ferrucci H; Universidad Nacional de La Amazonía Peruana, Loreto, Peru., Soto-Calle VE; Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru., Nelli L; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.; School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK., Byrne I; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Hill M; University of Surrey, Guildford, UK., Dumont E; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Grignard L; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Tetteh K; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Wu L; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Llanos-Cuentas A; Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru., Drakeley C; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Stresman G; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.; College of Public Health, Epidemiology Concentration, University of South Florida, Tampa, FL, USA., Carrasco-Escobar G; Health Innovation Laboratory, Institute of Tropical Medicine 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru.; Scripps Institution of Oceanography, University of California San Diego, San Diego, CA, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Feb 02; Vol. 14 (1), pp. 2806. Date of Electronic Publication: 2024 Feb 02.
DOI: 10.1038/s41598-024-52239-5
Abstrakt: Despite progress towards malaria reduction in Peru, measuring exposure in low transmission areas is crucial for achieving elimination. This study focuses on two very low transmission areas in Loreto (Peruvian Amazon) and aims to determine the relationship between malaria exposure and proximity to health facilities. Individual data was collected from 38 villages in Indiana and Belen, including geo-referenced households and blood samples for microscopy, PCR and serological analysis. A segmented linear regression model identified significant changes in seropositivity trends among different age groups. Local Getis-Ord Gi* statistic revealed clusters of households with high (hotspots) or low (coldspots) seropositivity rates. Findings from 4000 individuals showed a seropositivity level of 2.5% (95%CI: 2.0%-3.0%) for P. falciparum and 7.8% (95%CI: 7.0%-8.7%) for P. vivax, indicating recent or historical exposure. The segmented regression showed exposure reductions in the 40-50 age group (β1 = 0.043, p = 0.003) for P. vivax and the 50-60 age group (β1 = 0.005, p = 0.010) for P. falciparum. Long and extreme distance villages from Regional Hospital of Loreto exhibited higher malaria exposure compared to proximate and medium distance villages (p < 0.001). This study showed the seropositivity of malaria in two very low transmission areas and confirmed the spatial pattern of hotspots as villages become more distant.
(© 2024. The Author(s).)
Databáze: MEDLINE
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