'Eczematous' dermatitis of the nipple: clinical and histopathological differential diagnosis of Paget disease.

Autor: Zengin HB; University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, Rochester, NY, USA. Electronic address: Hatice_Zengin@URMC.Rochester.edu., Tan PH; Luma Medical Centre, Pathology, Royal Square Medical Centre, Singapore., Liu R; University of Rochester Medical Center, Department of Dermatology, Rochester, NY, USA., Smoller BR; University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, Rochester, NY, USA; University of Rochester Medical Center, Department of Dermatology, Rochester, NY, USA.
Jazyk: angličtina
Zdroj: Pathology [Pathology] 2024 Apr; Vol. 56 (3), pp. 300-312. Date of Electronic Publication: 2024 Jan 06.
DOI: 10.1016/j.pathol.2023.10.018
Abstrakt: The nipple can be affected by many malignant and benign entities. A wide variety of diseases including Paget disease, atopic dermatitis and nipple candidiasis can cause eczema-like changes in the nipple. In cases of diagnostic uncertainty, tissue sampling may be indicated. A true eczematous lesion, such as atopic dermatitis, typically shows a spongiotic dermatitis pattern. Paget disease, on the other hand, presents with infiltration of the nipple epidermis by neoplastic cells. The presence of atypical cells scattered in the epidermis in a pagetoid pattern opens up a histopathological differential diagnosis encompassing squamous cell carcinoma in situ and malignant melanoma, among others. Immunohistochemistry is commonly used to render a diagnosis. The objective of this article is to discuss Paget disease and highlight relevant clinical and histopathological differential diagnoses.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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