Effect of histamine-receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study.

Autor: Ely MR; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA., Mangum JE; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA., Needham KW; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA., Minson CT; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA., Halliwill JR; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2024 Feb; Vol. 12 (3), pp. e15936.
DOI: 10.14814/phy2.15936
Abstrakt: The purpose of this study was to gain insight into histamine's role in the exercise inflammatory response and recovery from exercise. To explore this, young healthy participants (n = 12) performed 300 eccentric leg extensions under control (Placebo) versus histamine H 1 and H 2 receptor antagonism (Blockade) in a randomized cross-over study. Circulating leukocytes and cytokines were measured for 72 h after exercise. Circulating leukocytes were elevated at 6 and 12 h after exercise (p < 0.05) with the peak response being a 44.1 ± 11.7% increase with Blockade versus 13.7 ± 6.6% with Placebo (both p < 0.05 vs. baseline, but also p < 0.05 between Blockade and Placebo). Of the cytokines that were measured, only MCP-1 was elevated following exercise. The response at 6 h post-exercise was a 104.0 ± 72.5% increase with Blockade versus 93.1 ± 41.9% with Placebo (both p < 0.05 vs. baseline, p = 0.82 between Blockade and Placebo). The main findings of the present investigation were that taking combined histamine H 1 and H 2 receptor antagonists augmented the magnitude but not the duration of the increase of circulating immune cells following exercise. This suggests histamine is not only exerting a local influence within the skeletal muscle but that it may influence the systemic inflammatory patterns.
(© 2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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