NIR-responsive micropatterned nanocomposite functionalized implant for sequential antibacterial and osteogenesis.

Autor: Chen H; School of Material Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, GuangDong Engineering Technology Research Center of Metallic Materials Surface Functionalization, South China University of Technology, Guangzhou 510641, China., Fan Y; School of Material Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, GuangDong Engineering Technology Research Center of Metallic Materials Surface Functionalization, South China University of Technology, Guangzhou 510641, China., Shi Z; National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Engineering of Guangdong Province, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China., Liu C; School of Material Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, GuangDong Engineering Technology Research Center of Metallic Materials Surface Functionalization, South China University of Technology, Guangzhou 510641, China., Ran M; School of Material Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, GuangDong Engineering Technology Research Center of Metallic Materials Surface Functionalization, South China University of Technology, Guangzhou 510641, China., Zhai J; School of Material Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, GuangDong Engineering Technology Research Center of Metallic Materials Surface Functionalization, South China University of Technology, Guangzhou 510641, China., Wu J; Department of Orthopaedics and Traumatology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam 999077, China., Wong TM; Department of Orthopaedics and Traumatology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam 999077, China., Ning C; School of Material Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, GuangDong Engineering Technology Research Center of Metallic Materials Surface Functionalization, South China University of Technology, Guangzhou 510641, China., Yu P; School of Material Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, GuangDong Engineering Technology Research Center of Metallic Materials Surface Functionalization, South China University of Technology, Guangzhou 510641, China. Electronic address: imyup@scut.edu.cn.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Mar; Vol. 235, pp. 113748. Date of Electronic Publication: 2024 Jan 26.
DOI: 10.1016/j.colsurfb.2024.113748
Abstrakt: The long-term durability of the implant is influenced by two significant clinical challenges, namely bacterial infection and fixation loosening. Conventional implant materials have failed to meet the demands of the dynamic process of infectious bone repair, which necessitates early-stage bacterial sterilization and a conducive environment for late-stage osteogenesis. Consequently, there is an urgent requirement for an implant material that can sequentially regulate antibacterial properties and promote osteogenesis. The study aimed to develop a micropatterned graphene oxide nanocomposite on titanium implant (M-NTO/GO) for the sequential management of bacterial infection and osteogenic promotion. M-NTO/GO exhibited a micropattern nanostructure surface and demonstrated responsiveness to near-infrared (NIR) light. Upon NIR light irradiation, M-NTO/GO exhibited effective antibacterial properties, achieving antibacterial rates of 96.9% and 98.6% against E. coli and S. aureus, respectively. Under no-light condition, the micropatterned topography of M-NTO/GO exhibited the ability to induce directed cell growth, enhance cell adhesion and spreading, and facilitate osteogenic differentiation. These findings suggest the successful development of a functionalized micropatterned nanocomposite implant capable of sequentially regulating antibacterial and osteogenesis activity. Consequently, this highly effective strategy holds promise for expanding the potential applications of orthopedic implants.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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