| Autor: |
Bostanci E; Medicine Faculty, Department of Urology, Abant Izzet Baysal University, Bolu, Turkey., Kirkik D; Hamidiye Medicine Faculty, Department of Medical Biology, University of Health Sciences, Istanbul, Turkey., Kalkanli Tas S; Hamidiye Medicine Faculty, Department of Immunology, University of Health Sciences, Istanbul, Turkey., Uyeturk U; Medicine Faculty, Department of Urology, Abant Izzet Baysal University, Bolu, Turkey. |
| Jazyk: |
angličtina |
| Zdroj: |
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2024 Feb 02, pp. 1-12. Date of Electronic Publication: 2024 Feb 02. |
| DOI: |
10.1080/15257770.2024.2310710 |
| Abstrakt: |
Bladder cancer (BC) has shown a significant global health concern with distinct pathological, genetic, and epigenetic characteristics. Its prevalence is influenced by various risk factors, including age, gender, and genetic predisposition. This study investigates the association between BC and the Sirtuin 1 (SIRT1) gene polymorphism rs369274325 in the Turkish population. Genomic DNA was isolated from peripheral blood samples and genotyping of rs369274325 polymorphism in SIRT 1 was investigated in 200 individuals (in 100 Turkish bladder cancer patients and 100 healthy individuals as the control group.) by real-time PCR. Demographic information, smoking and alcohol consumption status was analyzed by statistical analysis. Statistical analysis was performed by Pearson's Chi-square test. Smoking and alcohol consumption were significantly higher in BC patients compared to controls ( p < 0.00018 and p < 0.0001, respectively). The genotypic distribution of SIRT1 rs369274325 did not show a significant difference between BC patients and controls ( p = 0.5550). BC, influenced by genetic and environmental factors, has been linked to various gene mutations. SIRT1, involved in diverse physiological processes, is proposed to play a role in BC. However, our study did not find a significant association between SIRT1 rs369274325 polymorphism and BC in the Turkish population. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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