Association of Intermediate-Stage Age-Related Macular Degeneration with Plasma Inflammatory Biomarkers in Persons with AIDS.
Autor: | Jabs DA; Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Wilmer Eye Institute, the Department of Ophthalmology, the Johns Hopkins University School of Medicine, Baltimore, Maryland., Schneider MF; Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Pak JW; Department of Ophthalmology and Visual Sciences, the University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Beck-Engeser G; Department of Medicine, the University of California, San Francisco, School of Medicine, San Francisco, California., Chan F; Department of Medicine, the University of California, San Francisco, School of Medicine, San Francisco, California., Ambayec GC; Department of Medicine, the University of California, San Francisco, School of Medicine, San Francisco, California., Hunt PW; Department of Medicine, the University of California, San Francisco, School of Medicine, San Francisco, California. |
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Jazyk: | angličtina |
Zdroj: | Ophthalmology science [Ophthalmol Sci] 2023 Nov 23; Vol. 4 (3), pp. 100437. Date of Electronic Publication: 2023 Nov 23 (Print Publication: 2024). |
DOI: | 10.1016/j.xops.2023.100437 |
Abstrakt: | Purpose: To evaluate associations of plasma levels of inflammatory biomarkers with age-related macular degeneration (AMD) and cataract in persons with AIDS. Design: Nested case-control study (analysis 1) and nested cohort study (analysis 2). Participants: Analysis 1: persons with AIDS and incident intermediate-stage AMD (n = 26) and controls without AMD matched for age, race/ethnicity, and gender (n = 49) from The Longitudinal Study of Ocular Complications of AIDS. Analysis 2: 475 persons from LSOCA with baseline plasma biomarker levels followed prospectively for cataract. Methods: In both analyses, cryopreserved plasma specimens obtained at baseline were assayed for monocyte chemoattractant protein (MCP)-1 (CC motif chemokine ligand [CCL] 2), macrophage inflammatory protein (MIP)-1β (CCL4), soluble tumor necrosis factor receptor (sTNFR) 2, interleukin (IL)-18, and fractalkine (CX3 motif chemokine ligand 1 [CX3CL1]). Main Outcome Measures: Analysis 1: mean difference (cases - controls) in plasma biomarker levels. Analysis 2: incident cataract. Results: After adjusting for plasma human immunodeficiency virus RNA level, CD4+ T-cell count, and smoking, elevated baseline plasma levels of sTNFR2 and IL-18 (mean differences [cases - controls] 0.11 log Conclusions: When combined with previous data suggesting that AMD is associated with elevated plasma levels of C-reactive protein, soluble CD14, and possibly IL-6, the association of elevated plasma levels of sTNFR2 and IL-18 with incident AMD, but not with incident cataract, suggests that innate immune system activation, and possibly NLRP3 inflammasome activation, may play a role in the pathogenesis of AMD in this population. Financial Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article. (© 2023 by the American Academy of Ophthalmology.) |
Databáze: | MEDLINE |
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