Imaging a putative marker of brain cortisol regulation in alcohol use disorder.
| Autor: | Verplaetse TL; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Hillmer AT; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Yale PET Center, Yale School of Medicine, New Haven, CT, USA., Bhatt S; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Rusowicz A; Yale PET Center, Yale School of Medicine, New Haven, CT, USA., Li S; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Yale PET Center, Yale School of Medicine, New Haven, CT, USA., Nabulsi N; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Yale PET Center, Yale School of Medicine, New Haven, CT, USA., Matuskey D; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Yale PET Center, Yale School of Medicine, New Haven, CT, USA., Huang Y; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Yale PET Center, Yale School of Medicine, New Haven, CT, USA., McKee SA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Cosgrove KP; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Yale PET Center, Yale School of Medicine, New Haven, CT, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Neurobiology of stress [Neurobiol Stress] 2024 Jan 21; Vol. 29, pp. 100609. Date of Electronic Publication: 2024 Jan 21 (Print Publication: 2024). |
| DOI: | 10.1016/j.ynstr.2024.100609 |
| Abstrakt: | Background: Stress is a potent activator of the hypothalamic-pituitary-adrenal (HPA) axis, initiating the release of glucocorticoid hormones, such as cortisol. Alcohol consumption can lead to HPA axis dysfunction, including altered cortisol levels. Until recently, research has only been able to examine peripheral cortisol associated with alcohol use disorder (AUD) in humans. We used positron emission tomography (PET) brain imaging with the radiotracer [ 18 F]AS2471907 to measure 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a cortisol-regenerating enzyme, in people with AUD compared to healthy controls. Methods: We imaged 9 individuals with moderate to severe AUD (5 men, 4 women; mean age = 38 years) and 12 healthy controls (8 men, 4 women; mean age = 29 years). Participants received 93.5 ± 15.6 MBq of the 11β-HSD1 inhibitor radiotracer [ 18 F]AS2471907 as a bolus injection and were imaged for 150-180 min on the High-Resolution Research Tomograph. 11β-HSD1 availability was quantified by [ 18 F]AS2471907 volume of distribution ( V Results: Individuals with AUD consumed 52.4 drinks/week with 5.8 drinking days/week. Healthy controls consumed 2.8 drinks/week with 1.3 drinking days/week. Preliminary findings suggest that [ 18 F]AS2471907 V Conclusions: This is the first in vivo examination of 11β-HSD1 availability in individuals with AUD. Our data suggest higher brain availability of the cortisol-regenerating enzyme 11β-HSD1 in people with AUD (vs. controls), and that higher vmPFC 11β-HSD1 availability is related to greater alcohol consumption. Thus, in addition to the literature suggesting that people with AUD have elevated peripheral cortisol, our findings suggest there may also be heightened central HPA activity. These findings set the foundation for future hypotheses on mechanisms related to HPA axis function in this population. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.) |
| Databáze: | MEDLINE |
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