A Review on Role of Inflammation in Coronavirus Disease.

Autor: Lotfi A; Azerbaijan Medical University, Baku, Azerbaijan., Hajian P; Department of Anesthesiology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran., Abbasi L; Guilan University of Medical Sciences, Rasht, Iran., Gargari MK; Tabriz University of Medical Sciences, Tabriz, Iran., Fard NNG; Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Naderi D; Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Jazyk: angličtina
Zdroj: Endocrine, metabolic & immune disorders drug targets [Endocr Metab Immune Disord Drug Targets] 2024; Vol. 24 (13), pp. 1488-1505.
DOI: 10.2174/0118715303265274231204075802
Abstrakt: The respiratory illness known as COVID-19 is caused by the novel coronavirus, SARS-CoV-2. While the precise pathogenic mechanism of COVID-19 remains unclear, the occurrence of a cytokine storm subsequent to viral infection plays a pivotal role in the initiation and advancement of the disease. The infection of SARS-CoV-2 induces a state of immune system hyperactivity, leading to an excessive production of inflammatory cytokines. Consequently, the identification of the various signaling pathways implicated in the inflammation induced by COVID-19 will enable researchers to investigate new targets for therapeutic intervention.
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Databáze: MEDLINE