Replacement of tibialis cranialis tendon with polyester, silicone-coated artificial tendon preserves biomechanical function in rabbits compared to tendon excision only.

Autor: Easton KL; Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee - Knoxville, 306D Dougherty Engineering Bldg., 1512 Middle Drive, Knoxville, TN, 37996, USA., Hatch C; Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee - Knoxville, 306D Dougherty Engineering Bldg., 1512 Middle Drive, Knoxville, TN, 37996, USA., Stephens K; Biomedical Engineering, Duke University, Durham, NC, USA., Marler D; Alabama College of Osteopathic Medicine, Dothan, AL, USA., Fidelis O; Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee - Knoxville, 306D Dougherty Engineering Bldg., 1512 Middle Drive, Knoxville, TN, 37996, USA., Sun X; Research Computing Support, University of Tennessee, Knoxville, TN, USA., Bowers KM; College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA., Billings C; Veterinary Cardiology, MedVet Cincinnati, Cincinnati, OH, USA., Greenacre CB; College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA., Anderson DE; College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA., Crouch DL; Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee - Knoxville, 306D Dougherty Engineering Bldg., 1512 Middle Drive, Knoxville, TN, 37996, USA. dustin.crouch@utk.edu.
Jazyk: angličtina
Zdroj: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2024 Feb 02; Vol. 19 (1), pp. 108. Date of Electronic Publication: 2024 Feb 02.
DOI: 10.1186/s13018-024-04581-7
Abstrakt: Background: Artificial tendons may be an effective alternative to autologous and allogenic tendon grafts for repairing critically sized tendon defects. The goal of this study was to quantify the in vivo hindlimb biomechanics (ground contact pressure and sagittal-plane motion) during hopping gait of rabbits having a critically sized tendon defect of the tibialis cranialis and either with or without repair using an artificial tendon.
Methods: In five rabbits, the tibialis cranialis tendon of the left hindlimb was surgically replaced with a polyester, silicone-coated artificial tendon (PET-SI); five operated control rabbits underwent complete surgical excision of the biological tibialis cranialis tendon in the left hindlimb with no replacement (TE).
Results: At 8 weeks post-surgery, peak vertical ground contact force in the left hindlimb was statistically significantly less compared to baseline for the TE group (p = 0.0215). Statistical parametric mapping (SPM) analysis showed that, compared to baseline, the knee was significantly more extended during stance at 2 weeks post-surgery and during the swing phase of stride at 2 and 8 weeks post-surgery for the TE group (p < 0.05). Also, the ankle was significantly more plantarflexed during swing at 2 and 8 weeks postoperative for the TE group (p < 0.05). In contrast, there were no significant differences in the SPM analysis among timepoints in the PET-SI group for the knee or ankle.
Conclusions: Our findings suggest that the artificial tibialis cranialis tendon effectively replaced the biomechanical function of the native tendon. Future studies should investigate (1) effects of artificial tendons on other (e.g., neuromuscular) tissues and systems and (2) biomechanical outcomes when there is a delay between tendon injury and artificial tendon implantation.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje