Exploring the polarization of M1 and M2 macrophages in the context of skin diseases.

Autor: Apeku E; Department of Dermatology, The 1st Hospital of Shanxi Medical University; Graduate Department of Shanxi Medical University, Taiyuan, Shanxi, China., Tantuoyir MM; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. macasty1234@gmail.com., Zheng R; Department of Dermatology, The 1st Hospital of Shanxi Medical University, Taiyuan, Shanxi, China. zhengr2002@163.com., Tanye N; School of Automation Science and Engineering, Xi'an Jiaotong University, Xi'an, China.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2024 Feb 01; Vol. 51 (1), pp. 269. Date of Electronic Publication: 2024 Feb 01.
DOI: 10.1007/s11033-023-09014-y
Abstrakt: Macrophages are critical components of the immune system and play vital roles in pathogen defense, immune regulation, and tissue repair. These cells exhibit different polarization states depending on environmental signals, and the M1/M2 paradigm is a useful tool for comprehending these states. This review article comprehensively presents the underlying mechanisms of M1 and M2 macrophage polarization and examines their polarization in various skin diseases. Additionally, this paper discusses therapeutic strategies that target M1 and M2 macrophage polarization in skin diseases. A more profound understanding of macrophage polarization in skin diseases could provide valuable insights for the development of innovative therapeutic strategies.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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