The use of a systems approach to increase NAD + in human participants.

Autor: Henderson JD; Department of Applied Sciences, Northumbria University, Northumberland Road, Newcastle upon Tyne, NE1 8ST, UK.; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3B, Mærsk Tårnet, 7, Sal, 2200, København N, Denmark., Quigley SNZ; Department of Applied Sciences, Northumbria University, Northumberland Road, Newcastle upon Tyne, NE1 8ST, UK., Chachra SS; Nuchido Ltd. Dissington Hall, Dalton, Northumberland, NE18 0AD, UK., Conlon N; Nuchido Ltd. Dissington Hall, Dalton, Northumberland, NE18 0AD, UK. nichola@nuchido.com., Ford D; Department of Applied Sciences, Northumbria University, Northumberland Road, Newcastle upon Tyne, NE1 8ST, UK. dianne.ford@northumbria.ac.uk.
Jazyk: angličtina
Zdroj: Npj aging [NPJ Aging] 2024 Feb 01; Vol. 10 (1), pp. 7. Date of Electronic Publication: 2024 Feb 01.
DOI: 10.1038/s41514-023-00134-0
Abstrakt: Reversal or mitigation against an age-related decline in NAD + has likely benefits, and this premise has driven academic and commercial endeavour to develop dietary supplements that achieve this outcome. We used a systems-based approach to improve on current supplements by targeting multiple points in the NAD + salvage pathway. In a double-blind, randomised, crossover trial, the supplement - Nuchido TIME+® (NT) - increased NAD + concentration in whole blood. This was associated with an increase in SIRT1 and an increase in nicotinamide phosphoribosyltransferase (NAMPT) in peripheral blood mononucleocytes, lower concentrations of pro-inflammatory cytokines in plasma, including a reduction in interleukin 2 (IL2), a reduction in glycated serum protein and a shift in the glycosylation profile of immunoglobulin G (IgG) toward a younger biological age, all of which are likely to promote a healthier ageing trajectory.
(© 2024. The Author(s).)
Databáze: MEDLINE
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