Short- and Long-Term Mortality of Hospitalized Patients With Autoimmune Rheumatic Diseases and Serious Infections: A National Cohort Study.

Autor:	Sagy I; I. Sagy, MD, PhD, Rheumatology Disease Unit, and Clinical Research Center, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev; Iftachsagy@gmail.com., Schwarzfuchs O; O. Schwarzfuchs, BSc, Faculty of Health Sciences, Ben Gurion University of the Negev., Zeller L; L. Zeller, MD, E. Ling, MD, PhD, M. Abu-Shakra, MD, Rheumatology Disease Unit, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev., Ling E; L. Zeller, MD, E. Ling, MD, PhD, M. Abu-Shakra, MD, Rheumatology Disease Unit, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev., Babiev AS; A.S. Babiev, BSc, Clinical Research Center, Soroka University Medical Center, Beer Sheva, Israel., Abu-Shakra M; L. Zeller, MD, E. Ling, MD, PhD, M. Abu-Shakra, MD, Rheumatology Disease Unit, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev.
Jazyk:	angličtina
Zdroj:	The Journal of rheumatology [J Rheumatol] 2024 May 01; Vol. 51 (5), pp. 517-522. Date of Electronic Publication: 2024 May 01.
DOI:	10.3899/jrheum.2023-1063
Abstrakt:	Objective: Infectious conditions are a significant cause of mortality in autoimmune rheumatic diseases (ARD). Among patients hospitalized with an infection, we compared in-hospital and long-term (3-year) mortality between those with and without ARD. Methods: This retrospective analysis included members of the largest health maintenance organization in Israel, aged > 18 years at the first episode of infection, who required hospitalization during 2003-2019. We compared in-hospital mortality and the results of a 3-year landmark analysis of those who survived the index hospitalization between patients with ARD, according to disease subgroups, and patients without ARD. Additionally, we compared mortality outcomes among patients with ARD, according to subgroup diagnosis, matched in a 1:3 ratio by age, sex, and ethnicity to patients without ARD. Results: Included were 365,247 patients who were admitted for the first time with the diagnosis of a serious infection. Of these, we identified 9755 with rheumatoid arthritis (RA), 1351 with systemic lupus erythematosus, 2120 with spondyloarthritis (SpA), 584 with systemic sclerosis, and 3214 with vasculitis. In a matched multivariate analysis, the risk for in-hospital mortality was lower among patients with RA (odds ratio [OR] 0.89, 95% CI 0.81-0.97) and SpA (OR 0.77, 95% CI 0.63-0.94). In a similar analysis, the risk of 3-year mortality was lower among patients with RA (hazard ratio [HR] 0.82, 95% CI 0.78-0.86) and vasculitis (HR 0.86, 95% CI 0.80-0.93). Conclusion: Among patients hospitalized for an infection, the risk of in-hospital and 3-year mortality was not increased among those with ARD compared to those without ARD. (Copyright © 2024 by the Journal of Rheumatology.)
Databáze:	MEDLINE
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