Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID).

Autor: Rojas-Holguín A; Universidad de Extremadura, Departamento de Terapeútica Médico Quirúrgica, Facultad de Medicina y Ciencias de la Salud, Badajoz, Spain; Department of HBP Surgery and Liver Transplantation, Hospital Universitario de Badajoz, Badajoz, Spain., Fondevila-Campo C; Department of Surgery, Hospital Clinic, Barcelona, Spain; Department of Surgery, Hospital Universitario La Paz, Madrid, Spain., Sanjuanbenito A; Department of Surgery, Hospital Universitario Ramón y Cajal, Madrid, Spain., Fabregat-Prous J; Department of Surgery, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain., Secanella-Medayo L; Department of Surgery, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain., Rotellar-Sastre F; Department of Surgery, Clínica Universitaria de Navarra, Pamplona, Spain., Pardo-Sánchez F; Department of Surgery, Clínica Universitaria de Navarra, Pamplona, Spain., Prieto-Calvo M; Department of Surgery, Hospital Universitario Cruces, Baracaldo, Spain., Marín-Ortega H; Department of Surgery, Hospital Clínico Universitario San Carlos, Madrid, Spain., Sánchez-Cabús S; Department of Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Diez-Valladares L; Department of Surgery, Hospital Clínico Universitario San Carlos, Madrid, Spain., Alonso-Casado Ó; Department of Surgery, MD Anderson Cancer Center Madrid, Spain., González-Serrano C; Department of Surgery, Hospital Universitario Basurto, Bilbao, Spain., Rodríguez-Sanjuan JC; Department of Surgery, Hospital Universitario Marqués de Valdecilla, Santander, Spain., García-Plaza G; Department of Surgery, Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain., Jaén-Torrejimeno I; Department of HBP Surgery and Liver Transplantation, Hospital Universitario de Badajoz, Badajoz, Spain., Suárez-Muñoz MÁ; Department of Surgery, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain., Becerra-Massare A; Department of Surgery, Hospital Universitario Virgen de las Nieves, Granada, Spain., Rio PS; Department of Surgery, Hospital Alvaro Cunqueiro, Vigo, Spain., Pando E; Department of Hepato-pancreato-biliary and Transplant Surgery, Hospital Universitario Vall d'Hebron, Barcelona, Spain., López-Andújar R; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; Hepatology, HBP Surgery and Transplants, IIS La Fe, Hospital La Fe, Valencia, Spain., Muñoz-Forner E; Department of Surgery, Hospital Clínico Universitario de Valencia, Valencia, Spain., Rodriguez-López M; Department of Surgery, Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Pereira F; Department of Surgery, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain., Serrablo-Requejo A; Department of Surgery, Hospital Universitario Miguel Servet, Zaragoza, Spain., Turrión VS; Department of Surgery, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., Garrido MJ; Department of Surgery, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., Burdío F; Department of Surgery, Hospital del Mar, Barcelona, Spain., Martín-Pérez E; Department of Surgery, Hospital Universitario de La Princesa, Madrid, Spain., Estevan-Estevan R; Department of Surgery, Fundación Instituto Valenciano de Oncología, Valencia, Spain., López-Guerra D; Universidad de Extremadura, Departamento de Terapeútica Médico Quirúrgica, Facultad de Medicina y Ciencias de la Salud, Badajoz, Spain; Department of HBP Surgery and Liver Transplantation, Hospital Universitario de Badajoz, Badajoz, Spain., Castell-Gómez J; Department of Surgery, Hospital Universitario La Paz, Madrid, Spain., Salinas-Gómez J; Department of Surgery, Hospital Universitario La Paz, Madrid, Spain., López-Baena JÁ; Department of Surgery, Hospital Gregorio Marañon, Madrid, Spain., López-Ben S; Department of Surgery, Hospital Universitari Dr Josep Trueta, Girona, Spain., Solar-García L; Department of Surgery, Hospital Universitario Central de Asturias, Oviedo, Spain., Pérez-Alonso AJ; Department of Surgery, Hospital Universitario Virgen de las Nieves, Granada, Spain; Department of Surgery, Complejo Hospitalario de Jaén, Jaén, Spain., Martínez-Insfran LA; Department of Surgery, Hospital Universitario San Juan de Alicante, Alicante, Spain., Blas JL; Department of Surgery, Hospital Royo Villanova, Zaragoza, Spain., Cornejo M; Department of Surgery, Hospital Marina Baixa, Villajoyosa, Alicante, Spain., Gutierrez-Calvo A; Department of Surgery Hospital Universitario Principe de Asturias. Alcalá de Henares, Madrid, Spain., Pozo CD; Department of Surgery, Hospital Dr. Peset, Valencia, Spain., Ochando-Cerdan F; Department of Surgery, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain., Muñoz-Bellvís L; Department of Surgery, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain., Rebollar-Saenz J; Department of Surgery, Hospital Universitario de Álava, Álava, Spain., Sánchez B; Department of Surgery, Hospital Regional de Málaga, Málaga, Spain., Jover JM; Department of Surgery, Hospital Universitario de Getafe, Getafe, Madrid, Spain., Gómez-Bravo MÁ; Department of Surgery, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Ramia JM; Hepatology, HBP Surgery and Transplants, IIS La Fe, Hospital La Fe, Valencia, Spain; Department of Surgery, Hospital General Universitario de Alicante, Alicante, Spain., Blanco-Fernández G; Universidad de Extremadura, Departamento de Terapeútica Médico Quirúrgica, Facultad de Medicina y Ciencias de la Salud, Badajoz, Spain; Department of HBP Surgery and Liver Transplantation, Hospital Universitario de Badajoz, Badajoz, Spain. Electronic address: gerardoblanco@unex.es.
Jazyk: angličtina
Zdroj: Surgical oncology [Surg Oncol] 2024 Feb; Vol. 52, pp. 102039. Date of Electronic Publication: 2024 Jan 27.
DOI: 10.1016/j.suronc.2024.102039
Abstrakt: Background and Objectives: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease-free survival.
Methods: Multicenter retrospective study of patients undergoing pancreatic resection for RCC pancreatic metastases, from January 2010 to May 2020. Patients were grouped into two groups depending on whether they received a single pancreatic resection (SPS) or iterative pancreatic resection. Data on short and long-term outcome after pancreatic resection were collected.
Results: The study included 131 pancreatic resections performed in 116 patients. Thus, iterative pancreatic surgery (IPS) was performed in 15 patients. The mean length of time between the first pancreatic surgery and the second was 48.9 months (95 % CI: 22.2-56.9). There were no differences in the rate of postoperative complications. The DFS rates at 1, 3 and 5 years were 86 %, 78 % and 78 % vs 75 %, 50 % and 37 % in the IPS and SPS group respectively (p = 0.179). OS rates at 1, 3, 5 and 7 years were 100 %, 100 %, 100 % and 75 % in the IPS group vs 95 %, 85 %, 80 % and 68 % in the SPS group (p = 0.895).
Conclusion: Repeated pancreatic resection in case of relapse of pancreatic metastasis of RCC in the pancreatic remnant is justified, since it achieves OS results similar to those obtained after the first resection.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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