Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.

Autor:	Liimatta J; Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, Bern 3010, Switzerland.; Department for BioMedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.; Kuopio Pediatric Research Unit (KuPRU), University of Eastern Finland and Kuopio University Hospital, Kuopio 70200, Finland., Curschellas E; Department of Chemistry, Biochemistry and Pharmacy, Medical Faculty, University of Bern, Bern 3010, Switzerland., Altinkilic EM; Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, Bern 3010, Switzerland.; Department for BioMedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland., Naamneh Elzenaty R; Department for BioMedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland., Augsburger P; Department for BioMedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland., du Toit T; Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, Bern 3010, Switzerland.; Department for BioMedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.; Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland., Voegel CD; Department for BioMedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.; Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland., Breault DT; Department of Pediatrics, Harvard Medical School, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Flück CE; Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, Bern 3010, Switzerland.; Department for BioMedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland., Pignatti E; Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, Bern 3010, Switzerland.; Department for BioMedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.
Jazyk:	angličtina
Zdroj:	Endocrinology [Endocrinology] 2024 Jan 16; Vol. 165 (3).
DOI:	10.1210/endocr/bqae014
Abstrakt:	Cholesterol is the precursor of all steroids, but how cholesterol flux is controlled in steroidogenic tissues is poorly understood. The cholesterol exporter ABCG1 is an essential component of the reverse cholesterol pathway and its global inactivation results in neutral lipid redistribution to tissue macrophages. The function of ABCG1 in steroidogenic tissues, however, has not been explored. To model this, we inactivated Abcg1 in the mouse adrenal cortex, which led to an adrenal-specific increase in transcripts involved in cholesterol uptake and de novo synthesis. Abcg1 inactivation did not affect adrenal cholesterol content, zonation, or serum lipid profile. Instead, we observed a moderate increase in corticosterone production that was not recapitulated by the inactivation of the functionally similar cholesterol exporter Abca1. Altogether, our data imply that Abcg1 controls cholesterol uptake and biosynthesis and regulates glucocorticoid production in the adrenal cortex, introducing the possibility that ABCG1 variants may account for physiological or subclinical variation in stress response. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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