Efficacy and Safety of Lotilaner Ophthalmic Solution 0.25% in the Treatment of Demodex Blepharitis: A Systematic Review and Meta-Analysis.

Autor:	Abo Zeid M; Faculty of Medicine, Tanta University, Tanta, Egypt.; Medical Research Group of Egypt (MRGE), Negida Academy, Arlington, Massachusetts, USA., Elrosasy A; Faculty of Medicine, Cairo University, Cairo, Egypt., Abbas AW; Faculty of Medicine, Mansoura University, Mansoura, Egypt., Elganady A; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Rhab AE; Faculty of Medicine, Kafr El-Sheikh University, Kafr el-Sheikh, Egypt., Abu Serhan H; Department of Ophthalmology, Hamad Medical Corporation, Doha, Qatar.
Jazyk:	angličtina
Zdroj:	Ocular immunology and inflammation [Ocul Immunol Inflamm] 2024 Dec; Vol. 32 (10), pp. 2494-2505. Date of Electronic Publication: 2024 Feb 01.
DOI:	10.1080/09273948.2024.2309552
Abstrakt:	Purpose: To evaluate the safety and efficacy of Lotilaner ophthalmic solution 0.25% in the treatment of demodex blepharitis. Methods: PubMed, Web of Science, Scopus, and Embase databases were searched. RCTs comparing lotilaner with placebo or any other standard treatments were included. Outcomes of mean collarette grade (MCG), mite density (Md), meaningful collarette reduction (MCR), mite eradication (ME), were pooled as mean difference (MD), and the outcomes of erythema cure (EC), collarette cure (CC) adverse events (AE) as risk ratio (RR) with their 95% confidence interval (CI) between the two groups from baseline to the endpoint. Review Manager (Version 5.4.1) software was used to conduct all statistical analyses. Results: Four RCTs (947 patients) were included in this study. The overall effect favored the lotilaner group in terms of mean collarette grade upper lid (MD -0.99, 95% CI [-1.26, -0.72]), MCG lower lid (MD -0.57, 95% CI [-1.03, -0.11]), Md (MD -1.13, 95% CI [-1.47, -0.79]), MCR (MD 2.07, 95% CI [2.27, 3.21]), ME (MD 3.46, 95% CI [2.96, 4.04]). EC (RR 3.16, 95% CI [2.18 to 4.59]) and CC (RR 4.17, 95% CI [2.97 to 5.85]). No significant difference between the two groups in terms of AE (RR 1.25, 95% CI [0.75 to 2.06]). However, these findings are limited by significant heterogeneity in some of the reported outcomes. Conclusions: Our findings show that lotilaner might effectively treat Demodex blepharitis. However, further RCTs with larger and more diverse populations are needed to confirm these findings as some outcomes show significant heterogeneity.
Databáze:	MEDLINE
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