Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects.

Autor:	Christopher DJ; Department of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu, India., Isaac BTJ; Department of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu, India., John FB; Department of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu, India., Shankar D; Department of Pulmonary Medicine, Respiratory Therapist & Research Co-ordinator, Christian Medical College, Vellore, Tamil Nadu, India., Samuel P; Department of G.I. Sciences & Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India., Gupta R; Professor and Head of Respiratory Medicine, Christian Medical College, Vellore, Tamil Nadu, India., Thangakunam B; Department of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Jazyk:	angličtina
Zdroj:	PLOS global public health [PLOS Glob Public Health] 2024 Feb 01; Vol. 4 (2), pp. e0002884. Date of Electronic Publication: 2024 Feb 01 (Print Publication: 2024).
DOI:	10.1371/journal.pgph.0002884
Abstrakt:	After recovery from COVID-19, there is data to suggest potential long-term pulmonary sequelae and associated impairment of functional capacity. This cross-sectional study was designed to assess the impact on respiratory function in a cohort of Indian subjects. Subjects who had recovered from COVID-19 were recruited. Clinical symptoms, pulmonary function test results, 6-minute walk test (6MWT) results, St George's Respiratory questionnaire (SGRQ) and chest radiographs were obtained. Information on the COVID-19 illness during hospitalization, baseline laboratory biomarkers and the disease severity categories as outlined by WHO (asymptomatic, mild, moderate, severe and critical), were retrieved from the hospital records. The 'COVID pneumonia'(WHO category moderate, severe & critical) group was compared with the 'Mild COVID' (WHO category mild) group and likewise, the WHO category moderate and the WHO category severe/critical groups were compared. In 207 subjects, whose mean age was 48.7 years were assessed after an average of 63 days from onset of symptom, 35% had TLC< 80% (restrictive defect), 8.3% had FEV1/FVC<70% (obstructive defect) and 44.4% had diminished DLCO<80% (diffusing capacity). The 'COVID-19 pneumonia' group when compared to the 'mild COVID-19' group, had lower FVC% (77.85 VS 88.18; P = 0.001), TLC% (79.48 VS 87.91; P = 0.0002), DLCO% (75.30 VS 89.20; P<0.0001) and DLCO/VA% (105.6 VS 111.8; P = 0.032), decreased minimum oxygen saturation (94.89 VS 97.73; P<0.0001) and more subjects had a drop in saturation of ≥ 4% (21.69% VS 4.84%; P = 0.001) during the 6MWT, and a greater mean total SGRQ score (29.2 VS 11.0; P<0.0001). To our knowledge, this is the first such report on Indian subjects. We have shown that post-COVID-19 lung damage leads to significant impairment of lung function, quality of life and effort tolerance. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2024 Christopher et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze:	MEDLINE
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