| Autor: |
Wilkerson JL; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States., Tatum SM; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States., Holland WL; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States., Summers SA; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States. |
| Jazyk: |
angličtina |
| Zdroj: |
Physiological reviews [Physiol Rev] 2024 Jul 01; Vol. 104 (3), pp. 1061-1119. Date of Electronic Publication: 2024 Feb 01. |
| DOI: |
10.1152/physrev.00008.2023 |
| Abstrakt: |
Ceramides are signals of fatty acid excess that accumulate when a cell's energetic needs have been met and its nutrient storage has reached capacity. As these sphingolipids accrue, they alter the metabolism and survival of cells throughout the body including in the heart, liver, blood vessels, skeletal muscle, brain, and kidney. These ceramide actions elicit the tissue dysfunction that underlies cardiometabolic diseases such as diabetes, coronary artery disease, metabolic-associated steatohepatitis, and heart failure. Here, we review the biosynthesis and degradation pathways that maintain ceramide levels in normal physiology and discuss how the loss of ceramide homeostasis drives cardiometabolic pathologies. We highlight signaling nodes that sense small changes in ceramides and in turn reprogram cellular metabolism and stimulate apoptosis. Finally, we evaluate the emerging therapeutic utility of these unique lipids as biomarkers that forecast disease risk and as targets of ceramide-lowering interventions that ameliorate disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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