The role of serum asprosin levels in predicting the severity of coronary artery disease in patients with diabetes mellitus.

Autor: Yigitdol I; Department of Internal Medicine, University of Health Sciences-Adana City Training and Research Hospital, Adana, Turkey. ismail.yigitdol@gmail.com., Gulumsek E; Department of Internal Medicine, University of Health Sciences-Adana City Training and Research Hospital, Adana, Turkey., Demirtas D; Department of Hematology, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey., Ardic ML; Department of Cardiology, University of Health Sciences-Adana City Training and Research Hospital, Adana, Turkey., Baylan FA; Department of Biochemistry, University of Sutcu Imam, Kahramanmaras, Turkey., Ozturk HA; Department of Internal Medicine, University of Health Sciences-Adana City Training and Research Hospital, Adana, Turkey., Arici FN; Department of Internal Medicine, University of Health Sciences-Adana City Training and Research Hospital, Adana, Turkey., Seker T; Department of Cardiology, Medical Park Hospital, Adana, Turkey., Sumbul HE; Department of Internal Medicine, University of Health Sciences-Adana City Training and Research Hospital, Adana, Turkey.
Jazyk: angličtina
Zdroj: Irish journal of medical science [Ir J Med Sci] 2024 Jun; Vol. 193 (3), pp. 1239-1247. Date of Electronic Publication: 2024 Feb 01.
DOI: 10.1007/s11845-024-03616-6
Abstrakt: Background: Asprosin is an emerging biomarker that plays a role in metabolic diseases. This study investigates asprosin as a predictive marker for coronary artery disease (CAD) severity in diabetic patients.
Methods: Diabetic patients (n = 181) and healthy controls (n = 60) were analyzed. CAD severity was assessed using SYNTAX score. Diabetic patients were divided into 3 groups. Group 1 = patients without CAD, group 2 = patients with low SYNTAX score, and group 3 = patients with moderate-high SYNTAX score. Asprosin levels were measured for all participants using an enzyme-linked immunosorbent assay (ELISA).
Results: Asprosin levels were significantly higher in patient group compared to control group (p < 0.001). Asprosin levels were significantly higher in group 3 compared to group 1 and group 2 (p = 0.002). In logistic regression analysis, asprosin levels independently predicted patients with moderate-high SYNTAX scores. According to this analysis, 1 ng/mL increase in asprosin level was found to increase the risk of having moderate-high SYNTAX score by 14.1%. When the threshold value of asprosin level was set as 22.17 ng/mL, it predicted patients with moderate-high SYNTAX score with 63.6% sensitivity and 62.6% specificity. In multivariate regression analysis, SYNTAX score independently correlated with asprosin level.
Conclusion: This is the first study in the literature to demonstrate a positive correlation between asprosin levels and SYNTAX scores in diabetic patients with CAD. More comprehensive studies with larger groups are needed.
(© 2024. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)
Databáze: MEDLINE
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