The Nonclassic Psychedelic Ibogaine Disrupts Cognitive Maps.

Autor:	Ivan VE; Canadian Center for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada., Tomàs-Cuesta DP; Canadian Center for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada., Esteves IM; Canadian Center for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada., Curic D; Department of Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada., Mohajerani M; Canadian Center for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada., McNaughton BL; Canadian Center for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California., Davidsen J; Department of Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada., Gruber AJ; Canadian Center for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Jazyk:	angličtina
Zdroj:	Biological psychiatry global open science [Biol Psychiatry Glob Open Sci] 2023 Aug 05; Vol. 4 (1), pp. 275-283. Date of Electronic Publication: 2023 Aug 05 (Print Publication: 2024).
DOI:	10.1016/j.bpsgos.2023.07.008
Abstrakt:	Background: The ability of psychedelic compounds to profoundly alter mental function has been long known, but the underlying changes in cellular-level information encoding remain poorly understood. Methods: We used two-photon microscopy to record from the retrosplenial cortex in head-fixed mice running on a treadmill before and after injection of the nonclassic psychedelic ibogaine (40 mg/kg intraperitoneally). Results: We found that the cognitive map, formed by the representation of position encoded by ensembles of individual neurons in the retrosplenial cortex, was destabilized by ibogaine when mice had to infer position between tactile landmarks. This corresponded with increased neural activity rates, loss of correlation structure, and increased responses to cues. Ibogaine had surprisingly little effect on the size-frequency distribution of network activity events, suggesting that signal propagation within the retrosplenial cortex was largely unaffected. Conclusions: Taken together, these data support proposals that compounds with psychedelic properties disrupt representations that are important for constraining neocortical activity, thereby increasing the entropy of neural signaling. Furthermore, the loss of expected position encoding between landmarks recapitulated effects of hippocampal impairment, suggesting that disruption of cognitive maps or other hippocampal processing may be a contributing mechanism of discoordinated neocortical activity in psychedelic states. (© 2023 Published by Elsevier Inc on behalf of Society of Biological Psychiatry.)
Databáze:	MEDLINE
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