Exosomal microRNAs in regulation of tumor cells resistance to apoptosis.

Autor:	Salehi M; Department of Medical Genetics, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran.; Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran., Kamali MJ; Department of Medical Genetics, School of Medicine, Babol University of Medical Sciences, Babol, Iran., Arab D; Department of Human Genetics, Science and Research Branch, Islamic Azad University, Tehran, Iran., Safaeian N; Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Ashuori Z; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran., Maddahi M; Faculty of Dentistry, Yeditepe University, Istanbul, Turkey., Latifi N; Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Iran., Jahromi AM; School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Biochemistry and biophysics reports [Biochem Biophys Rep] 2024 Jan 17; Vol. 37, pp. 101644. Date of Electronic Publication: 2024 Jan 17 (Print Publication: 2024).
DOI:	10.1016/j.bbrep.2024.101644
Abstrakt:	Exosomes are a type of extracellular vesicle that contains bioactive molecules that can be secreted by most cells. Nevertheless, the content of these cells differs depending on the cell from which they originate. The exosome plays a crucial role in modulating intercellular communication by conveying molecular messages to neighboring or distant cells. Cancer-derived exosomes can transfer several types of molecules into the tumor microenvironment, including high levels of microRNA (miRNA). These miRNAs significantly affect cell proliferation, angiogenesis, apoptosis resistance, metastasis, and immune evasion. Increasing evidence indicates that exosomal miRNAs (exomiRs) are crucial to regulating cancer resistance to apoptosis. In cancer cells, exomiRs orchestrate communication channels between them and their surrounding microenvironment, modulating gene expression and controlling apoptosis signaling pathways. This review presents an outline of present-day knowledge of the mechanisms that affect target cells and drive cancer resistance to apoptosis. Also, our study looks at the regulatory role of exomiRs in mediating intercellular communication between tumor cells and surrounding microenvironmental cells, specifically stromal and immune cells, to evade therapy-induced apoptosis. Competing Interests: The authors declare that they have no competing interests. (© 2024 The Authors.)
Databáze:	MEDLINE
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