Fulminant Type 1 Diabetes Caused by DIHS Could Be Affected by the Reactivation of HHV-6.

Autor:	Makino H; Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan., Tohyama M; Department of Dermatology, National Hospital Organization Shikoku Cancer Center, Ehime 791-0280, Japan., Kawamura R; Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan., Takata Y; Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan., Osawa H; Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan., Onuma H; Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Oct 15; Vol. 109 (11), pp. e2024-e2030.
DOI:	10.1210/clinem/dgae058
Abstrakt:	Context: In the previous issue of this journal, we reported that the incidence of fulminant type 1 diabetes (FT1D) due to the drug-induced hypersensitivity syndrome (DIHS) in Japan is higher than that in the general population and is associated with HLAB62. On the other hand, the reactivation of human herpesvirus 6 (HHV-6), which has been reported to be associated with DIHS, was observed at a higher frequency, but its association with the development of FT1D was unclear. Objective: We aimed to clarify the relationship between the onset of FT1D and the reactivation of HHV-6. Methods: We conducted a literature search for cases of DIHS-induced FT1D in addition to previously reported cases and investigated the changes in the HHV-6 antibody titer before and after the onset of FT1D. Results: The HHV-6 antibody titer was increased just before or after the onset of FT1D in all 8 cases. In 1 case, HHV-6 DNA was also identified shortly before the onset of FT1D. Conclusion: These results indicate for the first time that the reactivation of HHV-6 is associated with the onset of FT1D caused by DIHS. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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