Does YAP influence cell proliferation and apoptosis in benign epithelial odontogenic lesions?

Autor: Gonçalo RIC; Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil., Sousa JT; Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil., Costa CSO; Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil., Mafra RP; Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil., Santos JLMD; Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil., da Silva LP; Oral Histopathology Service, Federal University of Campina Grande, Patos, PB, Brazil., Queiroz LMG; Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2024 Oct; Vol. 30 (7), pp. 4538-4546. Date of Electronic Publication: 2024 Jan 31.
DOI: 10.1111/odi.14882
Abstrakt: Objective: To analyze the immunohistochemical expression of YAP and its correlation with markers involved in cell proliferation and apoptosis in benign epithelial odontogenic lesions.
Study Design: The sample consisted of 95 cases of odontogenic lesions (25 dentigerous cysts, 30 non-syndromic odontogenic keratocysts, 30 conventional ameloblastomas, and 10 unicystic ameloblastomas) and 10 dental follicles used as normal odontogenic tissue. The histological sections were submitted to immunohistochemistry with YAP, cyclin D1, Ki-67, and Bcl-2 antibodies. Immunoexpression was analyzed qualitatively and quantitatively using an adapted method. The collected data were analyzed descriptively and statistically (p ≤ 0.05).
Results: The highest YAP expression was observed in odontogenic keratocysts, followed by unicystic ameloblastomas and conventional ameloblastomas, which exhibited moderate immunoreactivity predominantly in peripheral cells. Furthermore, significant differences in YAP immunoexpression were observed between the groups analyzed, with significant positive correlations between YAP and cyclin D1 in dentigerous cysts and unicystic ameloblastomas and between YAP and Ki-67 in unicystic ameloblastomas (p < 0.05). However, there were no statistically significant correlations between YAP and Bcl-2 immunoexpression in the groups studied.
Conclusion: YAP may influence epithelial cell proliferation in odontogenic cysts and tumors, suggesting its possible participation in the progression of the odontogenic lesions studied.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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