The oral microbiome of a family including Papillon-Lefèvre-syndrome patients and clinically healthy members.

Autor: Vályi P; Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, Szentkirályi u 47, Budapest, H1085, Hungary. valyi.peter@dent.semmelweis-univ.hu., Wirth R; Department of Biotechnology, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary.; Institute of Plant Biology, Biological Research Center, Temesvári krt 62, Szeged, H6726, Hungary., Minárovits J; Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza L. krt 64, Szeged, H6720, Hungary., Strang O; Department of Biotechnology, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary., Maróti G; Department of Biotechnology, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary.; Institute of Plant Biology, Biological Research Center, Temesvári krt 62, Szeged, H6726, Hungary., Kovács KL; Department of Biotechnology, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary.; Institute of Biophysics, Biological Research Center, Temesvári krt 62, Szeged, H6726, Hungary.
Jazyk: angličtina
Zdroj: BMC oral health [BMC Oral Health] 2024 Jan 31; Vol. 24 (1), pp. 158. Date of Electronic Publication: 2024 Jan 31.
DOI: 10.1186/s12903-024-03856-z
Abstrakt: Aims: The oral microbiota composition of patients diagnosed with Papillon-Lefèvre-syndrome and treated for several years were compared to those existing in the oral cavity of the clinically healthy family members and a cohort of patients having various stages of chronic periodontitis.
Materials and Methods: A family with two sisters affected with severe periodontitis and with the typical skin symptoms of Papillon-Lefèvre-syndrome, and symptomless parents and third sibling were investigated. The Patients received periodontal treatment for several years and their oral microbiome was analysed by amplicon sequencing. Data were evaluated by microbial cluster analysis.
Results: The microbiome of the patients with Papillon-Lefèvre-syndrome was predominated with Aggregatibacter actinomycetemcomitans and associated oral periodontopathogens. Although the clinically healthy family members showed no oral disorder, their microbiome resembled that of subjects having mild periodontitis.
Conclusions: Predominance of A. actinomycetemcomitans in the subgingival microbiome of patients with Papillon-Lefèvre-syndrome suggests that specific treatment strategies directed against this pathobiont may improve the oral health status of the affected individuals.
Trial Registration: The study was conducted in accordance with the Declaration of Helsinki and the ethical permission has been issued by the Human Investigation Review Board of the University of Szeged, Albert Szent-Györgyi Clinical Centre (Permission No. 63/2017-SZTE). September 19, 2017.  https://u-szeged.hu/klinikaikutatas/rkeb-altal-jovahagyott/rkeb-2017 .
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: