| Autor: |
Le HH; Department of Bacteriology, National Institute of Hygiene and Epidemiology, Vietnam., Nguyen AV; Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Vietnam., Vu LH; Department of Laser and Skin Care, National Hospital of Dermatology and Venereology, Vietnam.; Department of Dermatology and Venereology, Hanoi Medical University, Vietnam., Nguyen VTH; Department of Dermatology and Venereology, Hanoi Medical University, Vietnam.; Department of General Planning, National Hospital of Dermatology and Venereology, Vietnam., Pham HQ; Department of Microbiology, Mycology and Parasitology, National Hospital of Dermatology and Venereology, Vietnam., Le HV; Department of Dermatology and Venereology, Hanoi Medical University, Vietnam.; Department of Microbiology, Mycology and Parasitology, National Hospital of Dermatology and Venereology, Vietnam., Nguyen ST; Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Vietnam., Le HT; Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Vietnam., Dinh HV; Department of Psychiatry, Military Hospital 103, Vietnam Military Medical University, Vietnam., Le NV; Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Vietnam., Le TD; Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Vietnam., Le MN; Tay Nguyen Institute of Scientific Research, Vietnam Academy of Science and Technology, Vietnam., Nguyen VH; Molecular Pathology Department, Faculty of Medical Technology, Hanoi Medical University, Vietnam., Hoang KT; Department of Immunology, Vietnam Military Medical University, Vietnam., Le HHL; Department of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Vietnam.; Department of Biochemistry, Haematology and Immunology, National Hospital of Dermatology and Venereology, Vietnam. |
| Abstrakt: |
This cross-sectional study investigated the antimicrobial resistance (AMR) patterns of gram-negative pathogens isolated from 4,789 hospitalized patients with lower respiratory tract infections (LRTIs). Of the collected specimens, 1,325 (27.7%) tested positive for gram-negative bacteria. Acinetobacter baumannii (38.6%), Pseudomonas aeruginosa (33.5%), Klebsiella pneumoniae (18.7%), Escherichia coli (5.6%), and Klebsiella aerogenes (3.5%) were the most prevalent isolates. AMR analysis revealed high resistance rates (79.9%-100%) of A. baumannii isolates to multiple classes of antibiotics except amikacin, trimethoprim/sulfamethoxazole, and colistin. P. aeruginosa displayed low resistance to colistin (< 10%) but high resistance to other antibiotics. K. pneumoniae displayed high resistance rates of 90.0%-100.0% to most penicillins, whereas resistance rates were notably lower for colistin (7.1%) and amikacin (16.7%). K. aerogenes exhibited high resistance to various antibiotics and sensitivity to amikacin (95.1%), ampicillin (100.0%), and colistin (100.0%). E. coli isolates exhibited resistance to ampicillin (96.9%) and maximum sensitivity to several antibiotics. Our study identified significant AMR trends and highlighted the prevalence of multidrug-resistant strains (93.6% for K. aerogenes and 69.1%-92.4% for other isolates). These findings emphasize the urgent need for appropriate antibiotic management practices to combat AMR in gram-negative pathogens associated with LRTIs. |
