Establishing multifactorial risk factors for adult-onset hearing loss: A systematic review with topic modelling and synthesis of epidemiological evidence.

Autor: Tran Y; Macquarie University Hearing Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia. Electronic address: yvonne.tran@mq.edu.au., Tang D; Macquarie University Hearing Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia. Electronic address: d.tang@mq.edu.au., Lo C; Australian College of Applied Professions, Sydney, NSW 2000, Australia. Electronic address: Charles.Lo@acap.edu.au., Macken O; Department of Linguistics, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia. Electronic address: oonagh.macken@students.mq.edu.au., Newall J; Department of Linguistics, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia. Electronic address: john.newall@mq.edu.au., Bierbaum M; Australian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia. Electronic address: mia.bierbaum@mq.edu.au., Gopinath B; Macquarie University Hearing Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia. Electronic address: bamini.gopinath@mq.edu.au.
Jazyk: angličtina
Zdroj: Preventive medicine [Prev Med] 2024 Mar; Vol. 180, pp. 107882. Date of Electronic Publication: 2024 Jan 29.
DOI: 10.1016/j.ypmed.2024.107882
Abstrakt: Background: This systematic review explores the multifaceted nature of risk factors contributing to adult-onset HL. The objective was to synthesise the most recent epidemiological evidence to generate pooled proportional incidences for the identified risk factors.
Methods: We conducted an extensive search of electronic databases (MEDLINE, EMBASE, and psychINFO) for studies providing epidemiological evidence of risk factors associated with hearing loss. Topic modelling using Latent Dirichlet Allocation (LDA) was first conducted to determine how many risk factor themes were available from the papers. Data were analysed by calculating the pooled proportional incidence using a meta-analysis of proportions.
Results: From the 72 studies reviewed, six key risk factor themes emerged through LDA topic modelling. The review identified ototoxicity, primarily caused by cancer treatments and antibiotics, infectious diseases like COVID-19, occupational noise exposure, lifestyle factors, health conditions, biological responses, and age progression as significant risk factors for HL. The highest proportional incidence was found with cancer-related ototoxicity at 55.4% (95%CI: 39.0-70.7), followed closely by ototoxicity from infectious diseases at 50.0% (95%CI: 28.5-71.5). This high proportional incidence suggests the need to explore less destructive therapies and proactively monitor hearing function during treatments.
Conclusions: The findings of this review, combined with the synthesis of epidemiological evidence, enhance our understanding of hearing loss (HL) pathogenesis and highlight potential areas for intervention, thereby paving the way for more effective prevention and management of adult-onset hearing loss in our ageing global population.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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