Comprehensive review of melatonin as a promising nutritional and nutraceutical supplement.

Autor:	Kamfar WW; Department of Clinical Nutrition, Faculty of Applied Medical Sciences, UmmAl-Qura University, P.O. Box: 7067, Makkah, Saudi Arabia.; Medical Nutrition and Food Services Department, Almana Hospitals, Aziziah, Dammam, Saudi Arabia., Khraiwesh HM; Department of Nutrition and Food Processing, Faculty of Agricultural Technology, Al-Balqa' Applied University, Salt, Jordan., Ibrahim MO; Department of Nutrition and Food Technology, Faculty of Agriculture, Mu'tah University, Karak, Jordan., Qadhi AH; Department of Clinical Nutrition, Faculty of Applied Medical Sciences, UmmAl-Qura University, P.O. Box: 7067, Makkah, Saudi Arabia., Azhar WF; Department of Clinical Nutrition, Faculty of Applied Medical Sciences, UmmAl-Qura University, P.O. Box: 7067, Makkah, Saudi Arabia., Ghafouri KJ; Department of Clinical Nutrition, Faculty of Applied Medical Sciences, UmmAl-Qura University, P.O. Box: 7067, Makkah, Saudi Arabia., Alhussain MH; Department of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Riyadh, 11451, Saudi Arabia., Aldairi AF; Faculty of Applied Medical Sciences, Department of Clinical Laboratory Sciences, Umm Al-Qura University, Al Abdeyah, Makkah, 7607, Saudi Arabia., AlShahrani AM; Department of Basic Medical Sciences, College of Applied Medical Sciences, Khamis Mushayt, King Khalid University, Abha, 62561, Saudi Arabia., Alghannam AF; Lifestyle and Health Research Center, Health Sciences Research Center, Princess Nourah Bint Abdulrahman University, Riyadh, 84428, Saudi Arabia., Abdulal RH; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.; Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Al-Slaihat AH; Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman, Jordan., Qutob MS; Clinical Nutrition and Dietetics Department, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan., Elrggal ME; College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Ghaith MM; Faculty of Applied Medical Sciences, Department of Clinical Laboratory Sciences, Umm Al-Qura University, Al Abdeyah, Makkah, 7607, Saudi Arabia., Azzeh FS; Department of Clinical Nutrition, Faculty of Applied Medical Sciences, UmmAl-Qura University, P.O. Box: 7067, Makkah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Jan 08; Vol. 10 (2), pp. e24266. Date of Electronic Publication: 2024 Jan 08 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e24266
Abstrakt:	Background: Melatonin is an indoleamine hormone secreted by the pineal gland at night and has an essential role in regulating human circadian rhythms (the internal 24-h clock) and sleep-wake patterns. However, it has recently gained considerable attention for its demonstrated ability in disease management. This review discusses the major biological activities of melatonin, its metabolites as nutritional supplements, and its bioavailability in food sources. Methods: The information acquisition process involved conducting a comprehensive search across academic databases including PubMed, Scopus, Wiley, Embase, and Springer using relevant keywords. Only the most recent, peer-reviewed articles published in the English language were considered for inclusion. Results: The molecular mechanisms by which melatonin induces its therapeutic effects have been the subject of various studies. Conclusion: While melatonin was initially understood to only regulate circadian rhythms, recent studies indicate that it has a far-reaching effect on various organs and physiological systems, such as immunity, cardiovascular function, antioxidant defense, and lipid hemostasis. As a potent antioxidant, anti-cancer, anti-inflammatory, and immunoregulatory agent, multiple therapeutic applications have been proposed for melatonin. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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