Ferulic acid interventions ameliorate NDEA-CCl 4 -induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats.

Autor: Somade OT; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Ajayi BO; Department of Chemical Sciences, Faculty of Natural Sciences, Ajayi Crowther University, Oyo, Nigeria., Adeyi OE; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Dada TA; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Ayofe MA; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Inalu DC; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Ajiboye OI; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Shonoiki OM; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Adelabu AO; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Onikola RT; Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China., Isiaka ID; Center for Bacteria and Viruses Resources and Bioinformation, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China., Omotoso O; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., James AS; School of Biomedical Sciences, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA., Olaniyan TO; Instituto Politécnico Nacional, Centro de Biotecnologĭa Genómica, Reynosa 88710, Mexico., Adegoke AM; Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan 200005, Nigeria., Akamo AJ; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Oyinloye BE; Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB, 5454, Ado-Ekiti 360001, Nigeria., Adewole E; Industrial Chemistry Unit, Department of Chemical Sciences, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Jazyk: angličtina
Zdroj: Toxicology reports [Toxicol Rep] 2024 Jan 14; Vol. 12, pp. 119-127. Date of Electronic Publication: 2024 Jan 14 (Print Publication: 2024).
DOI: 10.1016/j.toxrep.2024.01.006
Abstrakt: Hepatocellular carcinoma is a prevalent form of liver cancer that is life threatening. Many chemically synthesized anti-cancer drugs have various degrees of side effects. Hence, this study investigated the effect of FEAC interventions on NDEA-CCl 4 -induced HCAR in male Wistar rats. HCAR was induced by intraperitoneal administration of 200 mg/kg of NDEA and 0.5 mL/kg CCl 4 (as a promoter of HCAR). Following the induction of HCAR, rats were treated differently with two different doses (25 and 50 mg/kg) of FEAC. HCAR induction was confirmed by the significant elevation of serum levels of ALT, AST, and α-FP. Also elevated significantly were liver levels of Akt/PKB, NF-κB, TNF-α, MDA, GSH, and activities of GST, SOD, and CAT, while levels of liver p53 and Nrf2 were significantly lowered compared with normal rats. Treatment interventions with both 25 and 50 mg/kg of FEAC against the DEN-CCl 4 -induced HCAR gave comparable effects, marked by a significant reduction in the levels of serum ALT, AST and α-FP, as well as liver levels of MDA, GSH, Akt/PKB, NF-κB, TNF-α, GST, SOD, and CAT, while levels of liver p53 and Nrf2 were significantly elevated compared with normal rats. Put together and judging by the outcomes of this study, FEAC being a potent antioxidant may also be potent against chemical-induced HCAR via upregulation of p53 and Nrf2, as well as downregulation of the Akt/PKB-NF-κB pathway in rats.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors. Published by Elsevier B.V.)
Databáze: MEDLINE
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