Magnitude and Durability of the Antibody Response to mRNA-Based Vaccination Among SARS-CoV-2 Seronegative and Seropositive Health Care Personnel.

Autor: Ciccone EJ; Division of Infectious Diseases, School of Medicine., Zhu DR; Department of Epidemiology, Gillings School of Global Public Health., Gunderson AK; Department of Epidemiology, Gillings School of Global Public Health., Hawke S; Department of Biostatistics, Gillings School of Global Public Health., Ajeen R; Institute for Global Health and Infectious Diseases., Lodge EK; Department of Epidemiology, Gillings School of Global Public Health., Shook-Sa BE; Department of Biostatistics, Gillings School of Global Public Health., Abernathy H; Institute for Global Health and Infectious Diseases., Garrett HE; Department of Epidemiology, Gillings School of Global Public Health., King E; Institute for Global Health and Infectious Diseases., Alavian N; Division of Hospital Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina., Reyes R; Division of Hospital Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina., Taylor JL; Institute for Global Health and Infectious Diseases., Beatty C; Department of Epidemiology and Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, New York., Chung C; Institute for Global Health and Infectious Diseases., Mendoza CE; Department of Epidemiology, Gillings School of Global Public Health., Weber DJ; Division of Infectious Diseases, School of Medicine.; Department of Epidemiology, Gillings School of Global Public Health., Markmann AJ; Division of Infectious Diseases, School of Medicine., Premkumar L; Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina., Juliano JJ; Division of Infectious Diseases, School of Medicine.; Department of Epidemiology, Gillings School of Global Public Health., Boyce RM; Division of Infectious Diseases, School of Medicine.; Department of Epidemiology, Gillings School of Global Public Health., Aiello AE; Department of Epidemiology and Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, New York.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2024 Jan 19; Vol. 11 (1), pp. ofae009. Date of Electronic Publication: 2024 Jan 19 (Print Publication: 2024).
DOI: 10.1093/ofid/ofae009
Abstrakt: Few studies have described changes in SARS-CoV-2 antibody levels in response to infection and vaccination at frequent intervals and over extended follow-up periods. The purpose of this study was to assess changes in SARS-CoV-2-specific antibody responses among a prospective cohort of health care personnel over 18 months with up to 22 samples per person. Antibody levels and live virus neutralization were measured before and after mRNA-based vaccination with results stratified by (1) SARS-CoV-2 infection status prior to initial vaccination and (2) SARS-CoV-2 infection at any point during follow-up. We found that the antibody response to the first dose was almost 2-fold higher in individuals who were seropositive prior to vaccination, although neutralization titers were more variable. The antibody response induced by vaccination appeared to wane over time but generally persisted for 8 to 9 months, and those who were infected at any point during the study had slightly higher antibody levels over time vs those who remained uninfected. These findings underscore the need to account for SARS-CoV-2 natural infection as a modifier of vaccine responses, and they highlight the importance of frequent testing of longitudinal antibody titers over time. Together, our results provide a clearer understanding of the trajectories of antibody response among vaccinated individuals with and without prior SARS-CoV-2 infection.
Competing Interests: Potential conflicts of interest. All authors: No reported conflicts.
(© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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