Nationwide surveillance identifies yellow fever and chikungunya viruses transmitted by various species of Aedes mosquitoes in Nigeria.

Autor:	Nwangwu UC; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria.; Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria., Oguzie JU; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Osun State, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria., Nwachukwu WE; Nigeria Centre for Disease Control, Nigeria., Onwude CO; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Dogunro FA; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Diallo M; Medical Zoology Center, Institut Pasteur de Dakar, Dakar, Senegal., Ezihe CK; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria.; Malaria Consortium, Nigeria., Agashi NO; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria.; Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria., Eloy EI; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Anokwu SO; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Anioke CC; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Ikechukwu LC; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Nwosu CM; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Nwaogo ON; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Ngwu IM; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Onyeanusi RN; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Okoronkwo AI; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Orizu FU; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Etiki MO; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Onuora EN; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Adeorike ST; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Osun State, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria., Okeke PC; Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria., Chukwuekezie OC; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Ochu JC; National Arbovirus and Vectors Research Centre (NAVRC), Enugu, Nigeria., Ibrahim SS; Department of Biochemistry, Bayero University, Kano, Kano State, Nigeria.; Centre for Research in Infectious Diseases (CRID), Yaoundé, Cameroon., Ifedayo A; Nigeria Centre for Disease Control, Nigeria., Ihekweazu C; Nigeria Centre for Disease Control, Nigeria., Happi CT; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Osun State, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 15. Date of Electronic Publication: 2024 Jan 15.
DOI:	10.1101/2024.01.15.575625
Abstrakt:	Background: Since its reemergence in 2017, yellow fever (YF) has been active in Nigeria. The Nigeria Centre for Disease Control (NCDC) has coordinated responses to the outbreaks with the support of the World Health Organization (WHO). The National Arbovirus and Vectors Research Centre (NAVRC) handles the vector component of these responses. This study sought to identify the vectors driving YF transmission and any of the targeted arboviruses and their distribution across states. Methods: Eggs, larvae and pupae as well as adult mosquitoes were collected in observational, analytical, and cross-sectional surveys conducted in sixteen YF outbreak states between 2017 and 2020. Adult mosquitoes (field-collected or reared from immature stages) were morphologically identified, and arboviruses were detected using RT-qPCR at the African Centre of Excellence for Genomics of Infectious Diseases (ACEGID). Results: Aedes mosquitoes were collected in eleven of the sixteen states surveyed and the mosquitoes in nine states were found infected with arboviruses. A total of seven Aedes species were collected from different parts of the country. Aedes aegypti was the most dominant (51%) species, whereas Aedes africanus was the least (0.2%). Yellow fever virus (YFV) was discovered in 33 (~26%) out of the 127 Aedes mosquito pools. In addition to YFV, the Chikungunya virus (CHIKV) was found in nine pools. Except for Ae. africanus , all the Aedes species tested positive for at least one arbovirus. YFV-positive pools were found in six (6) Aedes species while CHIKV-positive pools were only recorded in two Aedes species. Edo State had the most positive pools (16), while Nasarawa, Imo, and Anambra states had the least (1 positive pool). Breteau and house indices were higher than normal transmission thresholds in all but one state. Conclusion: In Nigeria, there is a substantial risk of arbovirus transmission by Aedes mosquitoes, with YFV posing the largest threat at the moment. This risk is heightened by the fact that YFV and CHIKV have been detected in vectors across outbreak locations. Hence, there is an urgent need to step up arbovirus surveillance and control activities in the country.
Databáze:	MEDLINE
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