Sonographic Characteristics and Pathology Correlation of Breast Imaging Reporting and Data System (BI-RADS) Category 4 Lesions.

Autor:	Khan P; Radiology, Aga Khan University, Karachi, PAK., Masroor I; Radiology, Aga Khan University, Karachi, PAK., Alam MS; Radiology, King Faisal Specialist Hospital and Research Centre, Medina, SAU., Salam A; Internal Medicine, Khyber Teaching Hospital, Peshawar, PAK., Ali Y; Internal Medicine, Nazareth Hospital, Philadelphia, USA., Khan MS; Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Dec 31; Vol. 15 (12), pp. e51410. Date of Electronic Publication: 2023 Dec 31 (Print Publication: 2023).
DOI:	10.7759/cureus.51410
Abstrakt:	Introduction: The Breast Imaging-Reporting and Database System (BI-RADS) category 4 is designated for breast lumps that do not display the typical features of malignancy but still raise enough suspicion to warrant a recommendation for a biopsy, as malignancy cannot be ruled out through imaging alone. The main objective of this study was to investigate the sonographic characteristics and pathology correlation of BI-RADS 4 breast lesions and determine the positive predictive rate of BI-RADS 4 lesions in diagnosing breast cancer, using histopathology as the gold standard. Methods: This was a cross-sectional study conducted at the Department of Radiology, Aga Khan University Hospital in Karachi, spanning from May 2021 to August 2022, with a duration of 15 months. The study focused on female patients over the age of 18 who presented with suspicious breast lesions on ultrasound. Both mammography and ultrasound-guided core needle biopsy were performed on these patients, followed by a detailed histopathological evaluation of the biopsy specimens. To calculate the positive predictive value (PPV), true positive cases were identified through both histopathology and ultrasonography. Results: A total of 227 cases were categorized as BI-RADS 4 lesions, with the patients' mean age being 47.8 ± 14.3 years (range: 17 - 88). Among the biopsied lesions, 101 cases were confirmed to be true positive for breast malignancies, resulting in a PPV for malignancy of 44.9%. Conversely, there were 124 false positive cases out of the 227 BI-RADS 4 category lesions (54.63%). The primary indication for presentation was a breast lump, and out of the 101 confirmed malignant cases, 70 (69.3%) were associated with malignancy. Conclusion: BI-RADS 4 can be utilized to assess suspicious breast lumps; however, for more reliable results and to avoid false negatives, histopathological confirmation should complement the imaging findings. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Khan et al.)
Databáze:	MEDLINE
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