Impulse control and related behavioral disorders (ICRD) in Idiopathic Parkinson's Disease treated with different dopamine agonists in Hong Kong: Is any dopamine agonist better?

Autor:	Wu HF; Department of Neurology, Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Yu ELM; Clinical Research Centre, Kowloon West Cluster, Hong Kong, China., Sheng B; Department of Neurology, Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Wong KK; Department of Neurology, Medicine and Geriatrics, Yan Chai Hospital, Hong Kong, China., Au Yeung M; Department of Neurology, Medicine and Geriatrics, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China., Wong WT; Department of Neurology, Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Kwan HH; Department of Neurology, Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Ng LP; Department of Neurology, Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Cheung CH; Department of Neurology, Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Lam YL; Department of Neurology, Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Chan YK; Department of Neurology, Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China.
Jazyk:	angličtina
Zdroj:	Clinical parkinsonism & related disorders [Clin Park Relat Disord] 2024 Jan 05; Vol. 10, pp. 100235. Date of Electronic Publication: 2024 Jan 05 (Print Publication: 2024).
DOI:	10.1016/j.prdoa.2024.100235
Abstrakt:	Objective: To assess the incidence of Impulse control and related behavioral disorders (ICRD) in Chinese Idiopathic Parkinson Disease (IPD) patients treated with different dopamine agonists (DA), and their clinical characteristics and associated risk factors. Methods: This was an observational cohort study based on clinical interviews and medical records of IPD patients treated with DA for >6 months in three hospitals in Hong Kong. The short version of Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP-S) was used to screen for ICRD. ICRD incidence among different DA, clinical characteristics and risk factors were examined. Results: Incidence of ICRD was analyzed in 311 patients taking their first, single DA. 43 patients (13.8 %) developed ICRD. The mean duration of IPD was 8.5 ± 5.6 years and median HY stage was 2.5. Bromocriptine and rotigotine users had lower ICRD incidence rate. Both pramipexole [adjusted HR 7.28 (2.46-21.54), p < 0.001] and ropinirole [adjusted HR 6.53 (2.67-15.99), p < 0.001] were independently associated with higher risk of ICRD compared to bromocriptine in multivariate analysis. Similarly, pramipexole and ropinirole appeared to carry higher risk compared to rotigotine but did not reach statistical significance. Male [adjusted HR 2.24 (1.07-4.72), p = 0.033], younger IPD onset [adjusted HR 2.99 (1.44-6.19) for onset < 50 year, p = 0.003] and history of psychiatric disorders [adjusted HR 2.80 (1.39-5.62), p = 0.004] were other independent risk factors. Conclusion: Bromocriptine and probably rotigotine carried a lower ICRD risk compared to pramipexole and ropinirole. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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