Poor Oral Health Is Associated With Inflammation, Aortic Valve Calcification, and Brain Volume Among Forager-Farmers.

Autor:	Trumble BC; School of Human Evolution and Social Change, Center for Evolution and Medicine, Institute of Human Origins, Arizona State University, Tempe, Arizona, USA., Schwartz M; School of Medicine, University of New Mexico, Albuquerque, New Mexico, USA., Ozga AT; Department of Biological Sciences, Halmos College of Arts and Sciences, Fort Lauderdale, Florida, USA., Schwartz GT; School of Human Evolution and Social Change, Center for Evolution and Medicine, Institute of Human Origins, Arizona State University, Tempe, Arizona, USA., Stojanowski CM; School of Human Evolution and Social Change, Center for Evolution and Medicine, Institute of Human Origins, Arizona State University, Tempe, Arizona, USA., Jenkins CL; School of Human Evolution and Social Change, Center for Evolution and Medicine, Institute of Human Origins, Arizona State University, Tempe, Arizona, USA., Kraft TS; Department of Anthropology, University of Utah, Salt Lake City, Utah, USA., Garcia AR; School of Human Evolution and Social Change, Center for Evolution and Medicine, Institute of Human Origins, Arizona State University, Tempe, Arizona, USA., Cummings DK; Economic Science Institute, Chapman University, Orange, California, USA., Hooper PL; Economic Science Institute, Chapman University, Orange, California, USA., Eid Rodriguez D; School of Medicine, Universidad de San Simón, Cochabamba, Bolivia., Buetow K; School of Human Evolution and Social Change, Center for Evolution and Medicine, Institute of Human Origins, Arizona State University, Tempe, Arizona, USA., Beheim B; Department of Human Behavior, Ecology and Culture, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany., Irimia A; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA., Thomas GS; Heart & Vascular Institute, MemorialCare Health System, Fountain Valley, CA and University of California Irvine, Orange, California, USA., Thompson RC; Department of Cardiology, Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA., Gatz M; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA., Stieglitz J; Insititue for Advanced Study, Toulouse School of Economics, Toulouse, France., Finch CE; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA., Gurven M; Integrative Anthropological Sciences, University of California Santa Barbara, Santa Barbara, California, USA., Kaplan H; Economic Science Institute, Chapman University, Orange, California, USA.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2024 May 01; Vol. 79 (5).
DOI:	10.1093/gerona/glae013
Abstrakt:	Poor oral health is associated with cardiovascular disease and dementia. Potential pathways include sepsis from oral bacteria, systemic inflammation, and nutritional deficiencies. However, in post-industrialized populations, links between oral health and chronic disease may be confounded because the lower socioeconomic exposome (poor diet, pollution, and low physical activity) often entails insufficient dental care. We assessed tooth loss, caries, and damaged teeth, in relation to cardiovascular and brain aging among the Tsimane, a subsistence population living a relatively traditional forager-horticulturalist lifestyle with poor dental health, but minimal cardiovascular disease and dementia. Dental health was assessed by a physician in 739 participants aged 40-92 years with cardiac and brain health measured by chest computed tomography (CT; n = 728) and brain CT (n = 605). A subset of 356 individuals aged 60+ were also assessed for dementia and mild cognitive impairment (n = 33 impaired). Tooth loss was highly prevalent, with 2.2 teeth lost per decade and a 2-fold greater loss in women. The number of teeth with exposed pulp was associated with higher inflammation, as measured by cytokine levels and white blood cell counts, and lower body mass index. Coronary artery calcium and thoracic aortic calcium were not associated with tooth loss or damaged teeth. However, aortic valve calcification and brain tissue loss were higher in those who had more teeth with exposed pulp. Overall, these results suggest that dental health is associated with indicators of chronic diseases in the absence of typical confounds, even in a population with low cardiovascular and dementia risk factors. (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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