Selective neural inhibition via photobiomodulation alleviates behavioral hypersensitivity associated with small sensory fiber activation.

Autor: Buzza A; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA., Tapas K; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA., Zhuo J; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA., Anders JJ; Department of Anatomy, Physiology, and Genetics, Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Lewis SJ; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA., Jenkins MW; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA., Moffitt M; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Jazyk: angličtina
Zdroj: Lasers in surgery and medicine [Lasers Surg Med] 2024 Mar; Vol. 56 (3), pp. 305-314. Date of Electronic Publication: 2024 Jan 30.
DOI: 10.1002/lsm.23762
Abstrakt: Objective: Photobiomodulation at higher irradiances has great potential as a pain-alleviating method that selectively inhibits small diameter nerve fibers and corresponding sensory experiences, such as nociception and heat sensation. The longevity and magnitude of these effects as a function of laser irradiation parameters at the nerve was explored.
Methods: In a rodent chronic pain model (spared nerve injury-SNI), light was applied directly at the sural nerve with four delivery schemes: two irradiance levels (7.64 and 2.55 W/cm 2 ) for two durations each, corresponding to either 4.8 or 14.4 J total energy, and the effect on sensory hypersensitivities was evaluated.
Results: At emitter irradiances of 7.64 W/cm 2 (for 240 s), 2.55 W/cm 2 (for 720 s), and 7.64 W/cm 2 (for 80 s) the heat hypersensitivity was relieved the day following photobiomodulation (PBM) treatment by 37 ± 8.1% (statistically significant, p < 0.001), 26% ± 6% (p = 0.072), and 28 ± 6.1% (statistically significant, p = 0.032), respectively, and all three treatments reduced the hypersensitivity over the course of the experiment (13 days) at a statistically significant level (mixed-design analysis of variance, p < 0.05). The increases in tissue temperature (5.3 ± 1.0 and 1.3 ± 0.4°C from 33.3°C for the higher and lower power densities, respectively) at the neural target were well below those typically associated with permanent action potential disruption.
Conclusions: The data from this study support the use of direct PBM on nerves of interest to reduce sensitivities associated with small-diameter fiber activity.
(© 2024 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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