Therapeutic strategies for drug-resistant Pseudomonas aeruginosa: Metal and metal oxide nanoparticles.

Autor: Zhan Y; Xiang Ya School of Public Health, Central South University, Changsha, Hunan, China.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha, Hunan, China., Hu H; Xiang Ya School of Public Health, Central South University, Changsha, Hunan, China.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha, Hunan, China., Yu Y; Xiang Ya School of Public Health, Central South University, Changsha, Hunan, China.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha, Hunan, China., Chen C; School of Public Health, Xiangnan University, Chenzhou, Hunan, China., Zhang J; Xiang Ya School of Public Health, Central South University, Changsha, Hunan, China.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha, Hunan, China., Jarnda KV; Xiang Ya School of Public Health, Central South University, Changsha, Hunan, China.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha, Hunan, China., Ding P; Xiang Ya School of Public Health, Central South University, Changsha, Hunan, China.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha, Hunan, China.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2024 Sep; Vol. 112 (9), pp. 1343-1363. Date of Electronic Publication: 2024 Jan 30.
DOI: 10.1002/jbm.a.37677
Abstrakt: Pseudomonas aeruginosa (PA) is a widely prevalent opportunistic pathogen. Multiple resistant strains of PA have emerged from excessive or inappropriate use of antibiotics, making their eradication increasingly difficult. Therefore, the search for highly efficient and secure novel antimicrobial agents is crucial. According to reports, there is an increasing exploration of nanometals for antibacterial purposes. The antibacterial mechanisms involving the nanomaterials themselves, the release of ions, and the induced oxidative stress causing leakage and damage to biomolecules are widely accepted. Additionally, the study of the cytotoxicity of metal nanoparticles is crucial for their antibacterial applications. This article summarizes the types of metal nanomaterials and metal oxide nanomaterials that can be used against PA, their respective unique antibacterial mechanisms, cytotoxicity, and efforts made to improve antibacterial performance and reduce toxicity, including combination therapy with other materials and antibiotics, as well as green synthesis approaches.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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