Effects of laparoscopic sleeve gastrectomy on thyroid hormones and relationship between metabolic parameters and long-term total weight loss.

Autor: Teke E; General Surgery Department, Haydarpaşa Numune Training and Research Hospital, Tıbbiyecaddesi No:23, Üsküdar, 34668, Istanbul, Turkey. dr.emreteke@gmail.com., Güneş Y; General Surgery Department, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy Mahallesi, Hastane Sokak, No:1/8, Ataşehir, 34752, Istanbul, Turkey., Çoruhlu B; General Surgery Department, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy Mahallesi, Hastane Sokak, No:1/8, Ataşehir, 34752, Istanbul, Turkey., Esen Bulut N; General Surgery Department, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy Mahallesi, Hastane Sokak, No:1/8, Ataşehir, 34752, Istanbul, Turkey., Fersahoglu MM; General Surgery Department, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy Mahallesi, Hastane Sokak, No:1/8, Ataşehir, 34752, Istanbul, Turkey., Ergin A; General Surgery Department, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy Mahallesi, Hastane Sokak, No:1/8, Ataşehir, 34752, Istanbul, Turkey., Sancak S; Department of Endocrinology and Metabolic Diseases, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy Mahallesi, Hastane Sokak, No:1/8, Ataşehir, 34752, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Surgical endoscopy [Surg Endosc] 2024 Apr; Vol. 38 (4), pp. 1807-1812. Date of Electronic Publication: 2024 Jan 30.
DOI: 10.1007/s00464-024-10693-2
Abstrakt: Background: Bariatric surgery has significant effects on metabolic parameters and hormone levels. However, the specific impact of laparoscopic sleeve gastrectomy (LSG) on thyroid hormones and other metabolic parameters remains unclear. This study aimed to investigate the short and long-term effects of LSG on thyroid hormone levels, HbA1c, and other metabolic parameters.
Methods: A total of 619 euthyroid patients without a history of thyroid disease or thyroid hormone replacement therapy were included in the study. Patients with diabetes were excluded from the study. Preoperative, 1-year postoperative, and 5-year postoperative levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), HbA1c, and other metabolic parameters were recorded and analyzed.
Results: LSG resulted in significant weight loss and improvements in metabolic parameters. At 1 year postoperatively, there were significant reductions in BMI, HbA1c, TSH, fT3, and triglyceride levels, while fT4 levels increased. A statistically significant negative correlation was found between preoperative HbA1c level and percentage of total weight loss (%TWL) value at the fifth postoperative year. Additionally, a statistically significant negative correlation was found between the 5-year change in TSH and %TWL.
Conclusion: Being the first study to predict long-term total weight loss based on preoperative HbA1c, it is significant. This finding has important implications for personalized patient management and could aid clinicians in identifying individuals who may benefit most from sleeve gastrectomy as a treatment modality. This is valuable in that it emphasizes multidisciplinary work, including the endocrinologist and dietician.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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