Postexercise reflex facilitation in Lambert-Eaton myasthenic syndrome.

Autor:	Poh M; Department of Neurology, Tan Tock Seng Campus, National Neuroscience Institute, Singapore mervyn.poh@gmail.com., Ming YC; Department of Medical Oncology, Tan Tock Seng Hospital, Singapore., Yanni PC; Department of Medical Oncology, Tan Tock Seng Hospital, Singapore., Ng GJ; Department of Neurology, Tan Tock Seng Campus, National Neuroscience Institute, Singapore., Ho YH; Department of Pathology, Tan Tock Seng Hospital, Singapore., Prasad K; Department of Neurology, Tan Tock Seng Campus, National Neuroscience Institute, Singapore., Thirugnanam U; Department of Neurology, Tan Tock Seng Campus, National Neuroscience Institute, Singapore.
Jazyk:	angličtina
Zdroj:	Practical neurology [Pract Neurol] 2024 Jul 16; Vol. 24 (4), pp. 338-341. Date of Electronic Publication: 2024 Jul 16.
DOI:	10.1136/pn-2023-004032
Abstrakt:	A 62-year-old woman had 6 months of proximal weakness, fatigue and occasional diplopia, symptoms normally suggesting myasthenia gravis or inflammatory myopathy. Postexercise reflex facilitation is a bedside clinical sign that points to a diagnosis of the rarer alternative, Lambert-Eaton myasthenic syndrome (LEMS). We confirmed this diagnosis using electrodiagnostic short exercise testing and serum assay for voltage-gated calcium channel antibodies. Further investigation identified a small cell neuroendocrine carcinoma of the gallbladder, not previously associated with LEMS. Postexercise reflex facilitation is an important bedside clinical finding that helps clinicians to distinguish LEMS from its mimics. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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