Elevated S100B urine levels predict seizures in infants complicated by perinatal asphyxia and undergoing therapeutic hypothermia.
Autor: | Bersani I; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy., Lapergola G; Neonatal Intensive Care Unit, G. d'Annunzio University of Chieti, Chieti, Italy., Patacchiola R; Neonatal Intensive Care Unit, G. d'Annunzio University of Chieti, Chieti, Italy., D'Adamo E; Neonatal Intensive Care Unit, G. d'Annunzio University of Chieti, Chieti, Italy., Stuppia L; Center for Advances Studies and Technology (CAST), G. d'Annunzio University, Chieti, Italy., de Laurenzi V; Center for Advances Studies and Technology (CAST), G. d'Annunzio University, Chieti, Italy., Damiani V; Center for Advances Studies and Technology (CAST), G. d'Annunzio University, Chieti, Italy., Cataldo I; Laboratory of Clinical Pathology, SS Annunziata Hospital, Chieti, Italy., Clemente K; Laboratory of Clinical Pathology, SS Annunziata Hospital, Chieti, Italy., Primavera A; Neonatal Intensive Care Unit, G. d'Annunzio University of Chieti, Chieti, Italy., Salomone R; Neonatal Intensive Care Unit, G. d'Annunzio University of Chieti, Chieti, Italy., Barbante E; Neonatal Intensive Care Unit, G. d'Annunzio University of Chieti, Chieti, Italy., Campi F; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy., Savarese I; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy., Ronci S; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy., Dotta A; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy., Braguglia A; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy., Longo D; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy., Gavilanes DAW; Department of Pediatrics and Neonatology, Maastricht University, Maastricht, The Netherlands., Gazzolo F; Magna Graecia University, Catanzaro, Italy., Serpero L; Department of Maternal, Fetal and Neonatal Medicine, SS Antonio, Biagio and C. Arrigo Hospital, Alessandria, Italy., Strozzi MC; Department of Pediatrics and Neonatology, Ospedale Cardinal Massaia, Asti, Italy., Maconi A; Social Security Administration Development and Promotion of Scientific Research Unit, SS Antonio, Biagio and C. Arrigo Hospital, Alessandria, Italy., Cassinari M; Department of Clinical Biochemistry, Transfusion and Regeneration Medicine Alessandria Hospital, Alessandria, Italy., Libener R; Department of Clinical Biochemistry, Transfusion and Regeneration Medicine Alessandria Hospital, Alessandria, Italy., Gazzolo D; Neonatal Intensive Care Unit, G. d'Annunzio University of Chieti, Chieti, Italy. |
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Jazyk: | angličtina |
Zdroj: | Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2024 Jan 30; Vol. 62 (6), pp. 1109-1117. Date of Electronic Publication: 2024 Jan 30 (Print Publication: 2024). |
DOI: | 10.1515/cclm-2023-1471 |
Abstrakt: | Objectives: Seizures (SZ) are one of the main complications occurring in infants undergoing therapeutic hypothermia (TH) due to perinatal asphyxia (PA) and hypoxic ischemic encephalopathy (HIE). Phenobarbital (PB) is the first-line therapeutic strategy, although data on its potential side-effects need elucidation. We investigated whether: i) PB administration in PA-HIE TH-treated infants affects S100B urine levels, and ii) S100B could be a reliable early predictor of SZ. Methods: We performed a prospective case-control study in 88 PA-HIE TH infants, complicated (n=44) or not (n=44) by SZ requiring PB treatment. S100B urine levels were measured at 11 predetermined monitoring time-points from first void up to 96-h from birth. Standard-of-care monitoring parameters were also recorded. Results: S100B significantly increased in the first 24-h independently from HIE severity in the cases who later developed SZ and requested PB treatment. ROC curve analysis showed that S100B, as SZ predictor, at a cut-off of 2.78 μg/L achieved a sensitivity/specificity of 63 and 84 %, positive/negative predictive values of 83 and 64 %. Conclusions: The present results offer additional support to the usefulness of S100B as a trustable diagnostic tool in the clinical daily monitoring of therapeutic and pharmacological procedures in infants complicated by PA-HIE. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.) |
Databáze: | MEDLINE |
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